口腔微生物群的糖语。

IF 2.8 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Molecular Oral Microbiology Pub Date : 2024-10-01 Epub Date: 2024-03-21 DOI:10.1111/omi.12456
Fiona F Hager-Mair, Susanne Bloch, Christina Schäffer
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引用次数: 0

摘要

口腔中蕴藏着多种多样、充满活力的细菌生物膜群落,它们对维护口腔健康至关重要,如果出现菌群失调,则会引发各种疾病。作为生物信息的无与伦比的载体,糖参与了影响口腔健康和疾病的基本过程。众所周知,细菌的糖基结构--包括糖蛋白、脂多糖(LPS)、细胞壁糖聚合物和外多糖等多种化合物--会影响细菌的生存能力,直接影响细菌的生理机能、免疫原性、生活方式以及相互作用和定植能力。因此,了解口腔细菌的糖基结构和编码糖语是阐明其致病机制和开发有针对性的治疗干预策略的关键。在已知的免疫学作用的驱动下,口腔糖生物学的大部分研究都是针对LPSs的,而最近,糖蛋白也越来越受到关注。这篇综述从多方面描绘了糖语言,重点关注在主要口腔细菌(如链球菌、牙龈卟啉单胞菌、连翘丹那菌和核酸镰刀菌)中表现出来的糖蛋白。我们首先定义了不同糖类共轭物的特征,然后总结了口腔细菌产生的糖类共轭物结构多样性的知识现状,描述了其生物合成途径,并列出了这些高能耗化合物的生物学作用。此外,我们还重点介绍了关于口腔糖基础设施对龋齿、牙周炎和全身性疾病的影响的新兴研究。通过整合现有知识并找出知识差距,这篇综述强调了研究口腔细菌所说的糖语言对于增进我们对口腔微生物学的了解和开发新型抗菌药物的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Glycolanguage of the oral microbiota.

Glycolanguage of the oral microbiota.

The oral cavity harbors a diverse and dynamic bacterial biofilm community which is pivotal to oral health maintenance and, if turning dysbiotic, can contribute to various diseases. Glycans as unsurpassed carriers of biological information are participating in underlying processes that shape oral health and disease. Bacterial glycoinfrastructure-encompassing compounds as diverse as glycoproteins, lipopolysaccharides (LPSs), cell wall glycopolymers, and exopolysaccharides-is well known to influence bacterial fitness, with direct effects on bacterial physiology, immunogenicity, lifestyle, and interaction and colonization capabilities. Thus, understanding oral bacterias' glycoinfrastructure and encoded glycolanguage is key to elucidating their pathogenicity mechanisms and developing targeted strategies for therapeutic intervention. Driven by their known immunological role, most research in oral glycobiology has been directed onto LPSs, whereas, recently, glycoproteins have been gaining increased interest. This review draws a multifaceted picture of the glycolanguage, with a focus on glycoproteins, manifested in prominent oral bacteria, such as streptococci, Porphyromonas gingivalis, Tannerella forsythia, and Fusobacterium nucleatum. We first define the characteristics of the different glycoconjugate classes and then summarize the current status of knowledge of the structural diversity of glycoconjugates produced by oral bacteria, describe governing biosynthetic pathways, and list biological roles of these energetically costly compounds. Additionally, we highlight emerging research on the unraveling impact of oral glycoinfrastructure on dental caries, periodontitis, and systemic conditions. By integrating current knowledge and identifying knowledge gaps, this review underscores the importance of studying the glycolanguage oral bacteria speak to advance our understanding of oral microbiology and develop novel antimicrobials.

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来源期刊
Molecular Oral Microbiology
Molecular Oral Microbiology DENTISTRY, ORAL SURGERY & MEDICINE-MICROBIOLOGY
CiteScore
6.50
自引率
5.40%
发文量
46
审稿时长
>12 weeks
期刊介绍: Molecular Oral Microbiology publishes high quality research papers and reviews on fundamental or applied molecular studies of microorganisms of the oral cavity and respiratory tract, host-microbe interactions, cellular microbiology, molecular ecology, and immunological studies of oral and respiratory tract infections. Papers describing work in virology, or in immunology unrelated to microbial colonization or infection, will not be acceptable. Studies of the prevalence of organisms or of antimicrobials agents also are not within the scope of the journal. The journal does not publish Short Communications or Letters to the Editor. Molecular Oral Microbiology is published bimonthly.
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