全面回顾 miRNA 簇在宫颈癌中的功能作用。

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2024-04-01 Epub Date: 2024-03-21 DOI:10.2217/epi-2023-0244

Srinath Sriharikrishnaa, Femi E John, Medha Bairy, Sachin Shetty, Padmanaban S Suresh, Shama P Kabekkodu

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引用次数: 0

摘要

宫颈癌（CC）对全球妇女的健康构成严重威胁。由多个 miRNA 编码基因组成的 microRNA 簇（MC）在基因调控中起着关键作用。包括环状 RNA 和 DNA 甲基化在内的各种因素控制着 MC 的表达。MC表达失调与CC的发展密切相关，会促进癌症特征的获得。某些 MC 因其在正常、恶性肿瘤前和肿瘤组织中的独特表达模式而有望用于诊断、预后和治疗选择。本综述解释了 MCs 的调控和生物功能，并强调了 CC 中 MC 表达异常的临床意义。

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A comprehensive review on the functional role of miRNA clusters in cervical cancer.

Cervical cancer (CC) poses a significant health threat in women globally. MicroRNA clusters (MCs), comprising multiple miRNA-encoding genes, are pivotal in gene regulation. Various factors, including circular RNA and DNA methylation, govern MC expression. Dysregulated MC expression correlates strongly with CC development via promoting the acquisition of cancer hallmarks. Certain MCs show promise for diagnosis, prognosis and therapy selection due to their distinct expression patterns in normal, premalignant and tumor tissues. This review explains the regulation and biological functions of MCs and highlights the clinical relevance of abnormal MC expression in CC.

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.