颌骨黄瘤:病例系列和文献综述。

IF 3.2 Q2 PATHOLOGY
Shankar Venkat, Mohammed N Islam, Indraneel Bhattacharyya, Donald M Cohen, F James Kratochvil, Tina R Woods, Seema Ganatra, Saja A Alramadhan
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引用次数: 0

摘要

背景:骨内黄瘤是一种罕见的良性病变,有时与脂质分泌过多有关。颌骨黄瘤(XJB)于1964年首次报道,迄今为止,英文文献中报道的病例不到50例。XJB的发病机制高度提示为反应过程或代谢状况:方法:从 4 家口腔颌面病理服务机构的档案中检索了 7 例 XJB。方法:从 4 家口腔颌面病理服务机构的档案中检索了 7 例 XJB,并对所有这些病例的临床、放射学和组织病理学特征进行了回顾性分析。对 S100 和 CD68 进行了免疫组化染色:结果:所有七例病例均累及下颌骨。患者年龄在13至69岁之间,男女比例均衡。一名患者有高脂血症病史,其他患者的病史和牙科病史均无异常。在大多数病例中,XJB 是在常规放射检查中偶然发现的。少数病例出现肿胀和皮质扩张。从影像学上看,病例通常表现为界限清晰的多房性或单房性病变,这些病变要么是放射状的,要么是放射状/不放射状混合型的。所有病灶均通过手术刮除治疗,在随后的随访中未发现复发。这七例病例均表现为片状泡沫状巨噬细胞。通过排除显微镜下特征重叠的实体,并结合临床、组织学、放射学和 IHC 图谱,可以确定诊断。免疫组化结果显示,所有病例的 CD68 均呈弥漫阳性,S100 阴性:XJB是一种病因不明的罕见病变,可能会模仿其他良性或反应性颌骨病变。由于其罕见性和潜在的诊断挑战,临床医生在评估放射性颌骨异常时必须保持警惕,并在鉴别中考虑 CXJ。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Xanthoma of the Jaw Bones: Cases Series and Review of Literature.

Background: Intraosseous xanthomas are rare benign lesions sometimes associated with excess lipid production. Xanthoma of the jaw bones (XJB) was first reported in 1964, and fewer than 50 cases have been reported in the English literature to date. The etiopathogenesis of XJB is highly suggestive of a reactive process or a metabolic condition.

Method: Seven cases of XJBs were retrieved from the archives of 4 oral and maxillofacial pathology services. Clinical, radiographic and histopathologic features of all these cases were retrospectively analyzed. Immunohistochemical (IHC) stains for S100 and CD68 were performed.

Results: All seven cases involved the mandible. Patients' age ranged between 13 and 69 years with an evenly distributed female to male ratio. One patient had a medical history of hyperlipidemia, but the medical and dental histories of the others were unremarkable. For most cases, XJB was an incidental finding discovered during routine radiographic examination. Swelling and cortical expansion were noted in a few cases. Radiographically, cases typically presented as either well-defined multilocular or unilocular lesions, which were either radiolucent or mixed radiolucent/radiopaque. All the lesions were treated with surgical curettage and no recurrence was observed during subsequent follow-ups. Each of the seven cases exhibited sheets of foamy macrophages. The diagnosis is established by exclusion of entities with overlapping microscopic features and involved correlation with the clinical, histological, radiographic and IHC profiles. Immunohistochemically, all the cases expressed diffuse positivity for CD68 and were negative for S100.

Conclusion: XJB is a rare lesion of unknown etiology, which may mimic other benign or reactive jaw lesions. Due to its rarity and the potential diagnostic challenges it presents, clinicians must remain vigilant and consider CXJ in their differential when assessing radiolucent jaw anomalies.

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来源期刊
CiteScore
5.70
自引率
9.50%
发文量
99
期刊介绍: Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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