Zuriñe Erana-Perez, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez
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引用次数: 0
摘要
多个研究领域的科学家正在广泛探索利用细胞外囊泡(EVs)进行药物递送。为了充分挖掘其治疗潜力,人们开发了多种装载 EVs 的方法。虽然外源性方法已被广泛使用,但近年来内源性方法也受到了极大关注。这种方法基于亲代细胞基因工程,适用于装载蛋白质和核酸等大型治疗生物大分子。我们回顾了最常用的 EV 装载方法,并强调了内源性方法相对于其他方法的固有优势。我们还研究了这种创新方法的最新进展和应用,为基于 EV 的疗法领域未来的各种治疗机会提供信息。
Genetically engineered loaded extracellular vesicles for drug delivery.
The use of extracellular vesicles (EVs) for drug delivery is being widely explored by scientists from several research fields. To fully exploit their therapeutic potential, multiple methods for loading EVs have been developed. Although exogenous methods have been extensively utilized, in recent years the endogenous method has gained significant attention. This approach, based on parental cell genetic engineering, is suitable for loading large therapeutic biomolecules such as proteins and nucleic acids. We review the most commonly used EV loading methods and emphasize the inherent advantages of the endogenous method over the others. We also examine the most recent advances and applications of this innovative approach to inform on the diverse therapeutic opportunities that lie ahead in the field of EV-based therapies.
期刊介绍:
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.