Hana Boucheta, Emna Zouaoui, Hana Ferkous, Anis Madaci, Krishna Kumar Yadav, Yacine Benguerba
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Advancing Diabetes Management: The Future of Enzyme-Less Nanoparticle-Based Glucose Sensors-A Review.
Background: Glucose is vital for biological processes, requiring blood sugar levels to be maintained between 3.88 and 6.1 mmol/L, especially during fasting. Elevated levels signal diabetes, a global concern affecting 537 million people, necessitating effective glucose-monitoring devices.
Method: Enzyme-based sensors, though selective, are sensitive to environmental factors. Nonenzymatic sensors, especially those with nanoparticles, offer stability, high surface area, and cost-effectiveness. Existing literature supports their immediate glucose oxidation, showcasing exceptional sensitivity.
Results: This review details nonenzymatic sensors, highlighting materials, detection limits, and the promise of nanoparticle-based designs, which exhibit enhanced sensitivity and selectivity in glucose detection.
Conclusion: Nanoparticle-based sensors, as reviewed, show potential for glucose monitoring, overcoming enzyme-based limitations. The conclusion suggests future directions for advancing these sensors, emphasizing ongoing innovation in this critical research area.
期刊介绍：
The Journal of Diabetes Science and Technology (JDST) is a bi-monthly, peer-reviewed scientific journal published by the Diabetes Technology Society. JDST covers scientific and clinical aspects of diabetes technology including glucose monitoring, insulin and metabolic peptide delivery, the artificial pancreas, digital health, precision medicine, social media, cybersecurity, software for modeling, physiologic monitoring, technology for managing obesity, and diagnostic tests of glycation. The journal also covers the development and use of mobile applications and wireless communication, as well as bioengineered tools such as MEMS, new biomaterials, and nanotechnology to develop new sensors. Articles in JDST cover both basic research and clinical applications of technologies being developed to help people with diabetes.
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