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引用次数: 0
摘要
银屑病是一种慢性炎症性皮肤病，以 Th17 T 细胞介导的炎症为特征。bimekizumab是一种针对细胞因子IL-17A和IL-17F的人源化单克隆抗体，是治疗银屑病的一种新兴疗法。评估 bimekizumab 的 I 期试验报告显示，该药具有很强的安全性、耐受性和临床疗效，最常见的治疗突发不良反应为轻度至中度。II 期试验对给药间隔进行了评估，结果表明，增加给药剂量或更频繁地使用 bimekizumab 导致的不良事件增加极少。III期试验和开放标签扩展研究表明，与安慰剂和活性对比药相比，bimekizumab能迅速产生持续的临床反应。Bimekizumab 在治疗银屑病方面具有很强的疗效，在治疗 Th17 介导的其他病症方面也具有潜力。
Psoriasis is a chronic inflammatory skin condition characterized by Th17 T cell-mediated inflammation. An emerging treatment option for psoriasis is bimekizumab, a humanized monoclonal antibody targeting cytokines IL-17A and IL-17F. Phase I trials evaluating bimekizumab reported strong safety, tolerability, and clinical efficacy with most common treatment emergent adverse events being mild to moderate in nature. Phase II trials evaluated dosing intervals, revealing that higher dosages or more frequent administration of bimekizumab resulted in minimal increases in adverse events. Phase III trials and open label extension studies demonstrated a rapid, sustained clinical response when compared with placebo and active comparators. Bimekizumab shows strong efficacy in the treatment of psoriasis and has potential in the treatment of other Th17-mediated pathologies.
期刊介绍：
Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field.
Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.
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