亚临床母体自身免疫性疾病导致先天性高度房室传导阻滞：病例报告和文献综述。

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology Pub Date : 2024-03-18 DOI:10.1016/j.carpath.2024.107634

Shelby E. Walcott , Christian H. Tan , Jason Wicker , Silvio Litovsky

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引用次数: 0

摘要

母体自身免疫性疾病是先天性心脏传导阻滞（CHB）最常见的病因，CHB是一种罕见疾病，其特征是由于母体自身抗体抗SSA/Ro和抗SSB/La导致胎儿房室结纤维化和钙化。我们报告了一名患有高度房室传导阻滞、房室结钙化、房室结心房通道钙化以及左右束支钙化的女性新生儿的全部尸检和临床信息，该新生儿由一名患有亚临床自身免疫性疾病的27岁女性所生。

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Subclinical maternal autoimmune disease leading to congenital high degree atrioventricular block: Case report and review of the literature

Maternal autoimmune disease is the most common cause of congenital heart block (CHB), a rare illness characterized by fibrosis and calcification of the fetal atrioventricular (AV) node due to maternal autoantibodies anti-SSA/Ro and anti-SSB/La. We report the full autopsy and clinical information on a female neonate with high degree AV block and calcification in the AV node, atrial approaches to the AV node, and both right and left bundle branches, born to a 27-year-old female with subclinical autoimmune disease.

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来源期刊

Cardiovascular Pathology 医学-病理学

CiteScore

7.50

自引率

2.70%

发文量

审稿时长

18 days

期刊介绍： Cardiovascular Pathology is a bimonthly journal that presents articles on topics covering the entire spectrum of cardiovascular disease. The Journal''s primary objective is to publish papers on disease-oriented morphology and pathogenesis from clinicians and scientists in the cardiovascular field. Subjects covered include cardiovascular biology, prosthetic devices, molecular biology and experimental models of cardiovascular disease.