Teresa Kraus, Natalia Shengelia-de Lange, Holger Einspieler, Marcus Hacker, Alexander Haug, Elisabeth Kretschmer-Chott, Georgios Karanikas
{"title":"分化型甲状腺癌放射性碘随访诊断扫描的价值","authors":"Teresa Kraus, Natalia Shengelia-de Lange, Holger Einspieler, Marcus Hacker, Alexander Haug, Elisabeth Kretschmer-Chott, Georgios Karanikas","doi":"10.1530/ec-24-0007","DOIUrl":null,"url":null,"abstract":"<p>Background: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO) the follow-up should consist of serum Tg assays and a neck ultrasound, while the American Thyroid Association (ATA) recommends serum Tg assays, neck ultrasounds, and a diagnostic radioiodine Whole Body Scan (WBS) if non-stimulated Tg is greater than 10ng/mL or if Tg is rising. This study questions the necessity of a diagnostic WBS in patients with low stimulated Tg levels during the initial follow-up. </p><p>Design: Retrospective data analysis.\n</p><p>Methods: The data of 185 patients, who were in regular treatment and aftercare between 2015 and 2018 at the Department of Nuclear Medicine in Vienna, as well as the data of 185 patients, who were treated in Tbilisi between 2015 and 2019, were analysed. </p><p>Results: There was a highly significant relationship between low stimulated Tg-levels (<0.5 ng/mL) and the outcome of the diagnostic WBS at the first follow-up (Χ<sup>2</sup> = 14.7, p < 0.001). A total of 31 of 370 patients (8.4%) had positive findings in the diagnostic WBS. 75 of 370 patients (19.74%) had stimulated Tg-levels >0.5 ng/ml. </p><p>Conclusion: Our data suggest that the first follow-up, four to twelve months after the initial therapy of DTC, including the measurement of basal and stimulated Tg levels and Tg antibody levels, does not mandate a diagnostic WBS on all patients.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":"145 1","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer\",\"authors\":\"Teresa Kraus, Natalia Shengelia-de Lange, Holger Einspieler, Marcus Hacker, Alexander Haug, Elisabeth Kretschmer-Chott, Georgios Karanikas\",\"doi\":\"10.1530/ec-24-0007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Background: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO) the follow-up should consist of serum Tg assays and a neck ultrasound, while the American Thyroid Association (ATA) recommends serum Tg assays, neck ultrasounds, and a diagnostic radioiodine Whole Body Scan (WBS) if non-stimulated Tg is greater than 10ng/mL or if Tg is rising. This study questions the necessity of a diagnostic WBS in patients with low stimulated Tg levels during the initial follow-up. </p><p>Design: Retrospective data analysis.\\n</p><p>Methods: The data of 185 patients, who were in regular treatment and aftercare between 2015 and 2018 at the Department of Nuclear Medicine in Vienna, as well as the data of 185 patients, who were treated in Tbilisi between 2015 and 2019, were analysed. </p><p>Results: There was a highly significant relationship between low stimulated Tg-levels (<0.5 ng/mL) and the outcome of the diagnostic WBS at the first follow-up (Χ<sup>2</sup> = 14.7, p < 0.001). A total of 31 of 370 patients (8.4%) had positive findings in the diagnostic WBS. 75 of 370 patients (19.74%) had stimulated Tg-levels >0.5 ng/ml. </p><p>Conclusion: Our data suggest that the first follow-up, four to twelve months after the initial therapy of DTC, including the measurement of basal and stimulated Tg levels and Tg antibody levels, does not mandate a diagnostic WBS on all patients.</p>\",\"PeriodicalId\":11634,\"journal\":{\"name\":\"Endocrine Connections\",\"volume\":\"145 1\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine Connections\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1530/ec-24-0007\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine Connections","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1530/ec-24-0007","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer
Background: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO) the follow-up should consist of serum Tg assays and a neck ultrasound, while the American Thyroid Association (ATA) recommends serum Tg assays, neck ultrasounds, and a diagnostic radioiodine Whole Body Scan (WBS) if non-stimulated Tg is greater than 10ng/mL or if Tg is rising. This study questions the necessity of a diagnostic WBS in patients with low stimulated Tg levels during the initial follow-up.
Design: Retrospective data analysis.
Methods: The data of 185 patients, who were in regular treatment and aftercare between 2015 and 2018 at the Department of Nuclear Medicine in Vienna, as well as the data of 185 patients, who were treated in Tbilisi between 2015 and 2019, were analysed.
Results: There was a highly significant relationship between low stimulated Tg-levels (<0.5 ng/mL) and the outcome of the diagnostic WBS at the first follow-up (Χ2 = 14.7, p < 0.001). A total of 31 of 370 patients (8.4%) had positive findings in the diagnostic WBS. 75 of 370 patients (19.74%) had stimulated Tg-levels >0.5 ng/ml.
Conclusion: Our data suggest that the first follow-up, four to twelve months after the initial therapy of DTC, including the measurement of basal and stimulated Tg levels and Tg antibody levels, does not mandate a diagnostic WBS on all patients.
期刊介绍：
Endocrine Connections publishes original quality research and reviews in all areas of endocrinology, including papers that deal with non-classical tissues as source or targets of hormones and endocrine papers that have relevance to endocrine-related and intersecting disciplines and the wider biomedical community.
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