三维打印壳聚糖基纳米生物材料用于生物医学和药物输送:前景看好的生物活性剂和技术的最新进展

IF 1.7 3区 化学 Q3 CHEMISTRY, ORGANIC
Seyed Morteza Naghib, Morteza Zarrineh, M. R. Mozafari
{"title":"三维打印壳聚糖基纳米生物材料用于生物医学和药物输送:前景看好的生物活性剂和技术的最新进展","authors":"Seyed Morteza Naghib, Morteza Zarrineh, M. R. Mozafari","doi":"10.2174/0113852728298168240222114449","DOIUrl":null,"url":null,"abstract":": 3D bioprinting is a novel technology that has gained significant attention recently due to its potential applications in developing simultaneously controlled drug delivery systems (DDSs) for administering several active substances, such as growth factors, proteins, and drug molecules. This technology provides high reproducibility and precise control over the fabricated constructs in an automated way. Chitosan is a naturalderived polysaccharide from chitin, found in the exoskeletons of crustaceans such as shrimp and crabs. Chitosan- based implants can be prepared using 3D bioprinting technology by depositing successive layers of chitosan- based bioink containing living cells and other biomaterials. The resulting implants can be designed to release drugs at a controlled rate over an extended period. The use of chitosan-based implants for drug delivery has several advantages over conventional drug delivery systems. Chitosan is biodegradable and biocompatible, so it can be safely used in vivo without causing any adverse effects. It is also non-immunogenic, meaning it does not elicit an immune response when implanted in vivo. Chitosan-based implants are also costeffective and can be prepared using simple techniques. 3D bioprinting is an emerging technology that has revolutionized the field of tissue engineering by enabling the fabrication of complex 3D structures with high precision and accuracy. It involves using computer-aided design (CAD) software to create a digital model of the desired structure, which is then translated into a physical object using a 3D printer. The printer deposits successive layers of bioink, which contains living cells and other biomaterials, to create a 3D structure that mimics the native tissue. One of the most promising applications of 3D bioprinting is developing drug delivery systems (DDSs) to administer several active substances, such as growth factors, proteins, and drug molecules. DDSs are designed to release drugs at a controlled rate over an extended period, which can improve therapeutic efficacy and reduce side effects. Chitosan-based implants have emerged as a promising candidate for DDSs due to their attractive properties, such as biodegradability, biocompatibility, low cost, and nonimmunogenicity. 3D bioprinting technology has emerged as a powerful tool for developing simultaneously controlled DDSs for administering several active substances. The rationale behind integrating 3D printing technology with chitosan-based scaffolds for drug delivery lies in the ability to produce customized, biocompatible, and precisely designed systems that enable targeted and controlled drug release. This novel methodology shows potential for advancing individualized healthcare, regenerative treatments, and the creation of cutting- edge drug delivery systems. This review highlights the potential applications of 3D bioprinting technology for preparing chitosan-based implants for drug delivery.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"3D Printing Chitosan-based Nanobiomaterials for Biomedicine and Drug Delivery: Recent Advances on the Promising Bioactive Agents and Technologies\",\"authors\":\"Seyed Morteza Naghib, Morteza Zarrineh, M. R. Mozafari\",\"doi\":\"10.2174/0113852728298168240222114449\",\"DOIUrl\":null,\"url\":null,\"abstract\":\": 3D bioprinting is a novel technology that has gained significant attention recently due to its potential applications in developing simultaneously controlled drug delivery systems (DDSs) for administering several active substances, such as growth factors, proteins, and drug molecules. This technology provides high reproducibility and precise control over the fabricated constructs in an automated way. Chitosan is a naturalderived polysaccharide from chitin, found in the exoskeletons of crustaceans such as shrimp and crabs. Chitosan- based implants can be prepared using 3D bioprinting technology by depositing successive layers of chitosan- based bioink containing living cells and other biomaterials. The resulting implants can be designed to release drugs at a controlled rate over an extended period. The use of chitosan-based implants for drug delivery has several advantages over conventional drug delivery systems. Chitosan is biodegradable and biocompatible, so it can be safely used in vivo without causing any adverse effects. It is also non-immunogenic, meaning it does not elicit an immune response when implanted in vivo. Chitosan-based implants are also costeffective and can be prepared using simple techniques. 3D bioprinting is an emerging technology that has revolutionized the field of tissue engineering by enabling the fabrication of complex 3D structures with high precision and accuracy. It involves using computer-aided design (CAD) software to create a digital model of the desired structure, which is then translated into a physical object using a 3D printer. The printer deposits successive layers of bioink, which contains living cells and other biomaterials, to create a 3D structure that mimics the native tissue. One of the most promising applications of 3D bioprinting is developing drug delivery systems (DDSs) to administer several active substances, such as growth factors, proteins, and drug molecules. DDSs are designed to release drugs at a controlled rate over an extended period, which can improve therapeutic efficacy and reduce side effects. Chitosan-based implants have emerged as a promising candidate for DDSs due to their attractive properties, such as biodegradability, biocompatibility, low cost, and nonimmunogenicity. 3D bioprinting technology has emerged as a powerful tool for developing simultaneously controlled DDSs for administering several active substances. The rationale behind integrating 3D printing technology with chitosan-based scaffolds for drug delivery lies in the ability to produce customized, biocompatible, and precisely designed systems that enable targeted and controlled drug release. This novel methodology shows potential for advancing individualized healthcare, regenerative treatments, and the creation of cutting- edge drug delivery systems. This review highlights the potential applications of 3D bioprinting technology for preparing chitosan-based implants for drug delivery.\",\"PeriodicalId\":10926,\"journal\":{\"name\":\"Current Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-03-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2174/0113852728298168240222114449\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0113852728298168240222114449","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0

摘要

三维生物打印技术是一种新型技术,最近因其在开发可同时控制的给药系统(DDS)以给药多种活性物质(如生长因子、蛋白质和药物分子)方面的潜在应用而备受关注。这种技术具有很高的可重复性,并能以自动化方式精确控制制造的结构。壳聚糖是从甲壳素中提取的天然多糖,存在于虾蟹等甲壳类动物的外骨骼中。使用三维生物打印技术可以制备以壳聚糖为基础的植入物,方法是连续沉积含有活细胞和其他生物材料的以壳聚糖为基础的生物墨水层。设计出的植入物可在较长时间内以可控速率释放药物。与传统的给药系统相比,使用壳聚糖基植入物给药具有多项优势。壳聚糖具有生物降解性和生物相容性,因此可以在体内安全使用,不会造成任何不良影响。此外,它还具有非免疫原性,这意味着在体内植入时不会引起免疫反应。壳聚糖基植入物还具有成本效益,可以用简单的技术制备。三维生物打印技术是一项新兴技术,通过高精度、高准确度地制造复杂的三维结构,彻底改变了组织工程领域。它包括使用计算机辅助设计(CAD)软件创建所需结构的数字模型,然后使用三维打印机将其转化为实物。打印机连续沉积含有活细胞和其他生物材料的生物墨水层,以创建模仿原生组织的三维结构。三维生物打印最有前途的应用之一是开发药物输送系统(DDS),以输送多种活性物质,如生长因子、蛋白质和药物分子。DDS 的设计目的是在较长时间内以可控速率释放药物,从而提高疗效并减少副作用。壳聚糖基植入物具有生物可降解性、生物相容性、低成本和非免疫原性等诱人特性,因此已成为 DDSs 的理想候选材料。三维生物打印技术已成为开发可同时控制多种活性物质给药的 DDSs 的有力工具。将三维打印技术与壳聚糖基支架整合用于给药的理由在于,该技术能够生产出定制化、生物相容性和精确设计的系统,从而实现有针对性的可控药物释放。这种新颖的方法显示出推动个性化医疗保健、再生治疗和创建尖端给药系统的潜力。本综述重点介绍了三维生物打印技术在制备基于壳聚糖的给药植入物方面的潜在应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
3D Printing Chitosan-based Nanobiomaterials for Biomedicine and Drug Delivery: Recent Advances on the Promising Bioactive Agents and Technologies
: 3D bioprinting is a novel technology that has gained significant attention recently due to its potential applications in developing simultaneously controlled drug delivery systems (DDSs) for administering several active substances, such as growth factors, proteins, and drug molecules. This technology provides high reproducibility and precise control over the fabricated constructs in an automated way. Chitosan is a naturalderived polysaccharide from chitin, found in the exoskeletons of crustaceans such as shrimp and crabs. Chitosan- based implants can be prepared using 3D bioprinting technology by depositing successive layers of chitosan- based bioink containing living cells and other biomaterials. The resulting implants can be designed to release drugs at a controlled rate over an extended period. The use of chitosan-based implants for drug delivery has several advantages over conventional drug delivery systems. Chitosan is biodegradable and biocompatible, so it can be safely used in vivo without causing any adverse effects. It is also non-immunogenic, meaning it does not elicit an immune response when implanted in vivo. Chitosan-based implants are also costeffective and can be prepared using simple techniques. 3D bioprinting is an emerging technology that has revolutionized the field of tissue engineering by enabling the fabrication of complex 3D structures with high precision and accuracy. It involves using computer-aided design (CAD) software to create a digital model of the desired structure, which is then translated into a physical object using a 3D printer. The printer deposits successive layers of bioink, which contains living cells and other biomaterials, to create a 3D structure that mimics the native tissue. One of the most promising applications of 3D bioprinting is developing drug delivery systems (DDSs) to administer several active substances, such as growth factors, proteins, and drug molecules. DDSs are designed to release drugs at a controlled rate over an extended period, which can improve therapeutic efficacy and reduce side effects. Chitosan-based implants have emerged as a promising candidate for DDSs due to their attractive properties, such as biodegradability, biocompatibility, low cost, and nonimmunogenicity. 3D bioprinting technology has emerged as a powerful tool for developing simultaneously controlled DDSs for administering several active substances. The rationale behind integrating 3D printing technology with chitosan-based scaffolds for drug delivery lies in the ability to produce customized, biocompatible, and precisely designed systems that enable targeted and controlled drug release. This novel methodology shows potential for advancing individualized healthcare, regenerative treatments, and the creation of cutting- edge drug delivery systems. This review highlights the potential applications of 3D bioprinting technology for preparing chitosan-based implants for drug delivery.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Current Organic Chemistry
Current Organic Chemistry 化学-有机化学
CiteScore
3.70
自引率
7.70%
发文量
76
审稿时长
1 months
期刊介绍: Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信