Nitara Fernando , Tony Tadic , Winnie Li , Tirth Patel , Jerusha Padayachee , Anna T. Santiago , Jennifer Dang , Peter Chung , Enrique Gutierrez , Catherine Coolens , Edward Taylor , Jeff D. Winter
{"title":"1.5 T 磁共振直线加速器上前列腺表观扩散系数值的重复性和再现性","authors":"Nitara Fernando , Tony Tadic , Winnie Li , Tirth Patel , Jerusha Padayachee , Anna T. Santiago , Jennifer Dang , Peter Chung , Enrique Gutierrez , Catherine Coolens , Edward Taylor , Jeff D. Winter","doi":"10.1016/j.phro.2024.100570","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and Purpose</h3><p>Integrated magnetic resonance linear accelerator (MR-Linac) systems offer potential for biologically based adaptive radiation therapy using apparent diffusion coefficient (ADC). Accurate tracking of longitudinal ADC changes is key to establishing ADC-driven dose adaptation. Here, we report repeatability and reproducibility of intraprostatic ADC using deformable image registration (DIR) to correct for inter-fraction prostate changes.</p></div><div><h3>Materials and Methods</h3><p>The study included within-fraction repeat ADC measurements for three consecutive fractions for 20 patients with prostate cancer treated on a 1.5 T MR-Linac. We deformably registered successive fraction T<sub>2</sub>-weighted images and applied the deformation vector field to corresponding ADC maps to align to fraction 2. We delineated gross tumour volume (GTV), peripheral zone (PZ) and prostate clinical target volume (CTV) regions-of-interest (ROIs) on T<sub>2</sub>-weighted MRI and copied to ADC maps. We computed intraclass correlation coefficients (ICC) and percent repeatability coefficient (%RC) to determine within-fraction repeatability and between-fraction reproducibility for individual voxels, mean and 10th percentile ADC values per ROI.</p></div><div><h3>Results</h3><p>The ICC between repeats and fractions was excellent for mean and 10th percentile ADC in all ROIs (ICC > 0.86), and moderate repeatability and reproducibility existed for individual voxels (ICC > 0.542). Similarly, low %RC within-fraction (4.2–17.9 %) mean and 10th percentile ADC existed, with greater %RC between fractions (10.2–36.8 %). Higher %RC existed for individual voxel within-fraction (21.7–30.6 %) and between-fraction (32.1–34.5 %) ADC.</p></div><div><h3>Conclusions</h3><p>Results suggest excellent ADC repeatability and reproducibility in clinically relevant ROIs using DIR to correct between-fraction anatomical changes. We established the precision of voxel-level ADC tracking for future biologically based adaptation implementation.</p></div>","PeriodicalId":36850,"journal":{"name":"Physics and Imaging in Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S240563162400040X/pdfft?md5=0bfdc83d67412f850f6edc15aad577ee&pid=1-s2.0-S240563162400040X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Repeatability and reproducibility of prostate apparent diffusion coefficient values on a 1.5 T magnetic resonance linear accelerator\",\"authors\":\"Nitara Fernando , Tony Tadic , Winnie Li , Tirth Patel , Jerusha Padayachee , Anna T. Santiago , Jennifer Dang , Peter Chung , Enrique Gutierrez , Catherine Coolens , Edward Taylor , Jeff D. Winter\",\"doi\":\"10.1016/j.phro.2024.100570\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and Purpose</h3><p>Integrated magnetic resonance linear accelerator (MR-Linac) systems offer potential for biologically based adaptive radiation therapy using apparent diffusion coefficient (ADC). Accurate tracking of longitudinal ADC changes is key to establishing ADC-driven dose adaptation. Here, we report repeatability and reproducibility of intraprostatic ADC using deformable image registration (DIR) to correct for inter-fraction prostate changes.</p></div><div><h3>Materials and Methods</h3><p>The study included within-fraction repeat ADC measurements for three consecutive fractions for 20 patients with prostate cancer treated on a 1.5 T MR-Linac. We deformably registered successive fraction T<sub>2</sub>-weighted images and applied the deformation vector field to corresponding ADC maps to align to fraction 2. We delineated gross tumour volume (GTV), peripheral zone (PZ) and prostate clinical target volume (CTV) regions-of-interest (ROIs) on T<sub>2</sub>-weighted MRI and copied to ADC maps. We computed intraclass correlation coefficients (ICC) and percent repeatability coefficient (%RC) to determine within-fraction repeatability and between-fraction reproducibility for individual voxels, mean and 10th percentile ADC values per ROI.</p></div><div><h3>Results</h3><p>The ICC between repeats and fractions was excellent for mean and 10th percentile ADC in all ROIs (ICC > 0.86), and moderate repeatability and reproducibility existed for individual voxels (ICC > 0.542). Similarly, low %RC within-fraction (4.2–17.9 %) mean and 10th percentile ADC existed, with greater %RC between fractions (10.2–36.8 %). Higher %RC existed for individual voxel within-fraction (21.7–30.6 %) and between-fraction (32.1–34.5 %) ADC.</p></div><div><h3>Conclusions</h3><p>Results suggest excellent ADC repeatability and reproducibility in clinically relevant ROIs using DIR to correct between-fraction anatomical changes. 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Repeatability and reproducibility of prostate apparent diffusion coefficient values on a 1.5 T magnetic resonance linear accelerator
Background and Purpose
Integrated magnetic resonance linear accelerator (MR-Linac) systems offer potential for biologically based adaptive radiation therapy using apparent diffusion coefficient (ADC). Accurate tracking of longitudinal ADC changes is key to establishing ADC-driven dose adaptation. Here, we report repeatability and reproducibility of intraprostatic ADC using deformable image registration (DIR) to correct for inter-fraction prostate changes.
Materials and Methods
The study included within-fraction repeat ADC measurements for three consecutive fractions for 20 patients with prostate cancer treated on a 1.5 T MR-Linac. We deformably registered successive fraction T2-weighted images and applied the deformation vector field to corresponding ADC maps to align to fraction 2. We delineated gross tumour volume (GTV), peripheral zone (PZ) and prostate clinical target volume (CTV) regions-of-interest (ROIs) on T2-weighted MRI and copied to ADC maps. We computed intraclass correlation coefficients (ICC) and percent repeatability coefficient (%RC) to determine within-fraction repeatability and between-fraction reproducibility for individual voxels, mean and 10th percentile ADC values per ROI.
Results
The ICC between repeats and fractions was excellent for mean and 10th percentile ADC in all ROIs (ICC > 0.86), and moderate repeatability and reproducibility existed for individual voxels (ICC > 0.542). Similarly, low %RC within-fraction (4.2–17.9 %) mean and 10th percentile ADC existed, with greater %RC between fractions (10.2–36.8 %). Higher %RC existed for individual voxel within-fraction (21.7–30.6 %) and between-fraction (32.1–34.5 %) ADC.
Conclusions
Results suggest excellent ADC repeatability and reproducibility in clinically relevant ROIs using DIR to correct between-fraction anatomical changes. We established the precision of voxel-level ADC tracking for future biologically based adaptation implementation.
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