感染 SARS-CoV-2 后，血浆 NEDD9 增高，并与肺血管功能障碍指数相关。

IF 2.2 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Pulmonary Circulation Pub Date : 2024-03-18 eCollection Date: 2024-01-01 DOI:10.1002/pul2.12356

George A Alba, Iris Y Zhou, Molly Mascia, Michael Magaletta, Jehan W Alladina, Francesca L Giacona, Leo C Ginns, Peter Caravan, Bradley A Maron, Sydney B Montesi

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引用次数: 0

摘要

与健康志愿者相比，SARS-CoV-2 感染后急性后遗症（PASC）患者的血浆中促血栓形成蛋白 NEDD9 水平升高，这与肺血管功能指数成反比。这表明持续性肺血管功能障碍可能在 PASC 的病理生物学中发挥作用。

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Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction.

Compared to healthy volunteers, participants with post-acute sequelae of SARS-CoV-2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular function. This suggests persistent pulmonary vascular dysfunction may play a role in the pathobiology of PASC.

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来源期刊

Pulmonary Circulation Medicine-Pulmonary and Respiratory Medicine

CiteScore

4.20

自引率

11.50%

发文量

153

审稿时长

15 weeks

期刊介绍： Pulmonary Circulation''s main goal is to encourage basic, translational, and clinical research by investigators, physician-scientists, and clinicans, in the hope of increasing survival rates for pulmonary hypertension and other pulmonary vascular diseases worldwide, and developing new therapeutic approaches for the diseases. Freely available online, Pulmonary Circulation allows diverse knowledge of research, techniques, and case studies to reach a wide readership of specialists in order to improve patient care and treatment outcomes.