治疗糖尿病的草药纳米制剂:机制、配方和临床影响。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Ms Sunita, Rahul Kaushik, Krishan Kumar Verma, Rehana Parveen
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引用次数: 0

摘要

背景:糖尿病仍然是一个全球性的健康挑战,需要创新的治疗策略。中草药因其在糖尿病治疗中的潜力而备受关注,而纳米技术的最新进展使得中草药纳米制剂的开发成为可能,这种制剂具有更高的疗效和生物利用度:本综述旨在全面分析中草药纳米制剂在控制糖尿病方面的机制、配方和临床影响:方法:通过系统的文献检索,找出探讨中药纳米制剂在糖尿病治疗中的作用机制、各种配方和临床效果的相关研究:草药纳米制剂通过多种机制发挥抗糖尿病作用,包括提高生物利用度、改善组织靶向性和增强胰岛素信号通路。各种草药成分,如苦瓜、葫芦巴和枸杞子,已被封装到纳米载体中,如脂质体、聚合物纳米颗粒和固体脂质纳米颗粒,以提高其治疗潜力。临床研究结果表明,这些药物在改善血糖控制、血脂状况和抗氧化状态的同时,不良反应极小:与传统草药制剂相比,纳米草药制剂具有更好的治疗效果,是治疗糖尿病的有效途径。有必要开展进一步研究,以优化配方策略,阐明长期安全性,并探索草药纳米制剂在糖尿病联合疗法中的潜在协同效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Herbal Nanoformulations for Diabetes: Mechanisms, Formulations, and Clinical Impact.

Background: Diabetes mellitus remains a global health challenge, demanding innovative therapeutic strategies. Herbal remedies have garnered attention for their potential in diabetes management, and recent advancements in nanotechnology have enabled the development of herbal nanoformulations with enhanced efficacy and bioavailability.

Objective: This review aimed to comprehensively analyze the mechanisms, formulations, and clinical impact of herbal nanoformulations in managing diabetes mellitus.

Method: A systematic literature search was conducted to identify relevant studies exploring the mechanisms of action, various formulations, and clinical outcomes of herbal nanoformulations in diabetes management.

Result: Herbal nanoformulations exert their anti-diabetic effects through multiple mechanisms, including enhanced bioavailability, improved tissue targeting, and potentiation of insulin signaling pathways. Various herbal ingredients, such as bitter melon, fenugreek, and Gymnema sylvestre, have been encapsulated into nanocarriers, like liposomes, polymeric nanoparticles, and solid lipid nanoparticles, to enhance their therapeutic potential. Clinical studies have demonstrated promising results, showing improvements in glycemic control, lipid profile, and antioxidant status with minimal adverse effects.

Conclusion: Herbal nanoformulations represent a promising avenue for the management of diabetes mellitus, offering improved therapeutic outcomes compared to conventional herbal preparations. Further research is warranted to optimize formulation strategies, elucidate long-term safety profiles, and explore the potential synergistic effects of herbal nanoformulations in combination therapies for diabetes management.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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