埃塞俄比亚中部一家三甲医院接受抗逆转录病毒治疗的患者中代谢综合征的决定因素：非匹配病例对照研究

IF 2.8 3区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Therapeutics and Clinical Risk Management Pub Date : 2024-03-18 DOI:10.2147/tcrm.s453699

Godana Jarso, Haji Aman, Abebe Megerso

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引用次数: 0

摘要

目的：扩大抗逆转录病毒治疗（ART）可降低艾滋病毒/艾滋病感染者（PLHA）的发病率和死亡率。但代谢综合征（MetS）等一系列相互关联的代谢紊乱使这一成功面临挑战。由于抗逆转录病毒疗法的疗程和时间不断变化、患者年龄不断增加以及方法学上的局限性，有关代谢综合征决定因素的现有证据仍无定论。因此，在本研究中，我们旨在确定在埃塞俄比亚中部一家三甲医院接受抗逆转录病毒疗法的患者中 MetS 的决定因素：我们进行了一项非匹配病例对照研究，共纳入 393 名患者，病例与对照的比例为 1:2。数据输入 Epi-Info 7.2 版，并使用 SPSS 26 版进行分析。二元逻辑回归分析用于确定 MetS 的决定因素。采用调整后的几率比（AOR）和 95% 的置信区间（CI）来估计 MetS 与其决定因素之间的关联强度。统计显著性以 p 值 < 0.05 为标准：在这项研究中，40-60 岁的患者（AOR 3.75；95% CI：1.66- 8.49）和 60 岁以上的患者（AOR 6.18；95% CI：2.12- 17.95）比 40 岁的患者患 MetS 的几率更高。同样，经常食用动物源性食物的患者比食用谷物或蔬菜的患者（AOR，1.94；95% CI，1.03- 3.63）、HIV 脂肪营养不良的患者（AOR 1.73；95% CI：1.05- 2.86）、接受司他夫定治疗者（AOR：3.08；95% CI：1.89- 5.04）和接受齐多夫定治疗者（AOR：1.71，95% CI：1.02- 2.88）与同龄人相比：结论：高龄、动物源性饮食、接触过齐多夫定或司他夫定以及存在脂肪营养不良是MetS的独立决定因素。

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Determinants of Metabolic Syndrome Among Patients Receiving Anti-Retro-Viral Treatment in A Tertiary Hospital, Central Ethiopia: Unmatched Case–Control Study

Purpose: Scaling up antiretroviral treatment (ART) reduces morbidity and mortality among people living with HIV/AIDS (PLHA). This success is challenged by the constellation of interrelated metabolic disorders such as metabolic syndrome (MetS). Given the changing ART regimens and schedules, increasing patient age and methodological limitations, existing evidence regarding the determinants of MetS remains inconclusive. Therefore, in the current study, we aimed to identify the determinants of MetS in patients receiving ART at a tertiary hospital in central Ethiopia.
Patient and Methods: We conducted an unmatched case–control study that included 393 patients with a case-to-control ratio of 1 to 2. Data were collected by interviewing patients, reviewing charts, physical examinations, and laboratory testing. The data were entered into Epi-Info version 7.2 and analyzed using SPSS version 26. A binary logistic regression analysis was used to identify the determinants of MetS. The adjusted odds ratio (AOR) with a 95% confidence interval (CI) was used to estimate the strength of the association between MetS and its determinants. Statistical significance was set at p-value < 0.05.
Results: In this study, higher odds of developing MetS were identified among patients aged 40– 60 years (AOR 3.75; 95% CI: 1.66– 8.49) and those older than 60 years (AOR 6.18; 95% CI: 2.12– 17.95) than among those aged < 40 years. Similarly, higher odds were observed among patients who frequently consumed animal source foods than among those who consumed cereals or vegetables (AOR, 1.94; 95% CI, 1.03– 3.63), those who had HIV lipodystrophy (AOR 1.73; 95% CI: 1.05– 2.86), those who were treated with stavudine (AOR 3.08; 95% CI: 1.89– 5.04), and those who were treated with zidovudine (AOR 1.71, 95% CI: 1.02– 2.88) compared to their counterparts.
Conclusion: Older age, diet from animal sources, exposure to zidovudine or stavudine, and the presence of lipodystrophy were independent determinants of MetS.

Keywords: adama, cardiometabolic, diabetes, dyslipidemia, hypertension, obesity

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来源期刊

Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-

CiteScore

5.30

自引率

3.60%

发文量

139

审稿时长

16 weeks

期刊介绍： Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.