心力衰竭的异常磷酸化/去磷酸化和 Ca2+ 功能障碍

IF 4.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Yan-Bing Liu, Qian Wang, Yu-Ling Song, Xiao-Min Song, Yu-Chen Fan, Lin Kong, Jing-Sai Zhang, Sheng Li, Yi-Ju Lv, Ze-Yang Li, Jing-Yu Dai, Zhen-Kang Qiu
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引用次数: 0

摘要

心力衰竭(HF)可由多种原因引起,以心肌收缩和舒张异常为特征。通过膜上 L 型钙通道(LTCC)的 Ca2+ 电流是心动周期的初始触发信号。心房颤动的收缩和舒张减弱与心肌 Ca2+ 功能障碍有关。这种失调与 LTCC、内质网(ER)和肌丝的磷酸化/去磷酸化水平失衡有关。激酶和磷酸酶的活性会随着高频的进展而变化,从而导致磷酸化/去磷酸化程度的阶段性变化。了解正常心脏和衰竭心脏的磷酸化/去磷酸化差异非常重要。本综述重点关注高房颤动进展过程中磷酸化/去磷酸化的变化,并根据以往的实验和临床研究总结了正常情况下和高房颤动中LTCC磷酸化/去磷酸化、ER功能和肌丝功能的影响。此外,我们还总结了目前基于异常磷酸化/去磷酸化的治疗方法,并阐明了潜在的治疗方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure

Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure

Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger signal for a cardiac cycle. Declined systole and diastole in HF are associated with dysfunction of myocardial Ca2+ function. This disorder can be correlated with unbalanced levels of phosphorylation / dephosphorylation of LTCC, endoplasmic reticulum (ER), and myofilament. Kinase and phosphatase activity changes along with HF progress, resulting in phased changes in the degree of phosphorylation / dephosphorylation. It is important to realize the phosphorylation / dephosphorylation differences between a normal and a failing heart. This review focuses on phosphorylation / dephosphorylation changes in the progression of HF and summarizes the effects of phosphorylation / dephosphorylation of LTCC, ER function, and myofilament function in normal conditions and HF based on previous experiments and clinical research. Also, we summarize current therapeutic methods based on abnormal phosphorylation / dephosphorylation and clarify potential therapeutic directions.

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来源期刊
Heart Failure Reviews
Heart Failure Reviews 医学-心血管系统
CiteScore
10.40
自引率
2.20%
发文量
90
审稿时长
6-12 weeks
期刊介绍: Heart Failure Reviews is an international journal which develops links between basic scientists and clinical investigators, creating a unique, interdisciplinary dialogue focused on heart failure, its pathogenesis and treatment. The journal accordingly publishes papers in both basic and clinical research fields. Topics covered include clinical and surgical approaches to therapy, basic pharmacology, biochemistry, molecular biology, pathology, and electrophysiology. The reviews are comprehensive, expanding the reader''s knowledge base and awareness of current research and new findings in this rapidly growing field of cardiovascular medicine. All reviews are thoroughly peer-reviewed before publication.
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