通过钌（II）催化的无受体脱氢偶联轻松合成 2-取代的喹唑啉类化合物

IF 1.7 3区化学 Q3 CHEMISTRY, ORGANIC

Current Organic Chemistry Pub Date : 2024-03-15 DOI:10.2174/0113852728290175240213050011

Shulei Wu, Qianqian Lei, Zaoduan Wu, Huifang Xie, Chen Zhang, Yu Ye, Meiling Yi, Mingsheng Chen, Hao Xu, Zehua Yang

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引用次数: 0

摘要

::本研究旨在开发一种实用、简便的 2-取代喹唑啉类化合物的单锅合成方法。以一种市售的、结构简单的钌( II) 复合物为催化剂，通过无受体脱氢偶联合成一系列喹唑啉衍生物。通过控制反应和 DFT 计算探索了该反应的机理。该方法可以获得多种喹唑啉衍生物（52 例），产率从中等到极好（29%-98%）不等。总之，我们开发出了一种在空气气氛下高效的一锅钌 (II) 催化 ADC 合成喹唑啉的方法。该反应只产生氢气和水作为副产物，是一种可持续的原子高效合成方法。

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Facile Synthesis of 2-Substituted Quinazolines via Ruthenium(II)-Catalyzed Acceptorless Dehydrogenative Coupling

:: This study aims to develop a practical and facile one-pot synthesis of 2- substituted quinazolines. Using a commercially available and structurally simple ruthenium( II) complex as the catalyst to synthesize a series of quinazoline derivatives via acceptorless dehydrogenative coupling. The mechanism of this reaction was explored by control reaction and DFT calculation. This protocol offers access to a diverse array of quinazoline derivatives (52 examples) in moderate to excellent yields (29%-98%). In summary, we have developed an efficient one-pot ruthenium (II)-catalyzed ADC synthesis of quinazoline under an air atmosphere. The reaction only produces hydrogen and water as by-products, serving as a sustainable and atom-efficient synthetic approach.

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来源期刊

Current Organic Chemistry 化学-有机化学

CiteScore

3.70

自引率

7.70%

发文量

审稿时长

1 months

期刊介绍： Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.