多分散球形颗粒扩散控制溶解的准稳态建模和特征描述,I:建模

IF 2.9 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Yanxing Wang, Hui Wan, Rusitan Refuaiti, Tie Wei, Fangjun Shu
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引用次数: 0

摘要

我们开发了一种准稳态模型(QSM),用于准确预测具有多种粒度和长宽比分布的多分散球形(扁球形、扁球形和球形)颗粒系统的详细扩散主导溶解过程。在基于均匀体积浓度假设的多分散溶解模型的成熟框架中,纳入了基于数学的单个球形颗粒溶解的严格 QSM。根据实验结果进行的验证表明,该模型可以准确预测具有各种粒度和形状参数的多分散体系的体积浓度增加情况。一系列涉及不同浓度比的多分散非洛地平颗粒溶解的代表性实例证明了该模型的有效性,使其成为了解和管理具有不同颗粒特征的复杂系统的重要工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quasi steady-state modelling and characterization of diffusion-controlled dissolution from polydisperse spheroidal particles, I: modelling

A quasi steady-state model (QSM) for accurately predicting the detailed diffusion-dominated dissolution process of polydisperse spheroidal (prolate, oblate and spherical) particle systems with a broad range of distributions of particle size and aspect ratio has been developed. A rigorous, mathematics-based QSM of the dissolution of single spheroidal particles has been incorporated into the well-established framework of polydisperse dissolution models based on the assumption of uniform bulk concentration. Validation against experimental results shows that this model can accurately predict the increase in bulk concentration of polydisperse systems with various particle sizes and shape parameters. A series of representative instances involving the dissolution of polydisperse felodipine particles at various concentration ratios is used to demonstrate the model's effectiveness, rendering it a valuable tool for understanding and managing complex systems with diverse particle characteristics.

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来源期刊
CiteScore
6.40
自引率
5.70%
发文量
227
审稿时长
3.0 months
期刊介绍: Proceedings A has an illustrious history of publishing pioneering and influential research articles across the entire range of the physical and mathematical sciences. These have included Maxwell"s electromagnetic theory, the Braggs" first account of X-ray crystallography, Dirac"s relativistic theory of the electron, and Watson and Crick"s detailed description of the structure of DNA.
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