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引用次数: 0
摘要
肿瘤相关巨噬细胞(TAMs)是调节肿瘤进展的肿瘤微环境(TME)的重要组成部分。肿瘤衍生信号、缺氧和对营养物质的竞争影响 TAMs 对其细胞代谢进行重编程。这种新陈代谢曲线的改变在肿瘤和其他免疫细胞之间形成了一种共生交流,从而支持了肿瘤的生长。此外,TAMs 的新陈代谢曲线还能调节免疫检查点分子的表达。动态可塑性还使 TAMs 能够根据现代治疗策略重塑其新陈代谢。因此,多年来已有大量方法可用于重塑 TAMs 的促癌代谢。在这篇综述中,我们将讨论当前的策略和陷阱,以及即将出现的利用 TAM 代谢开发更好的癌症治疗方法的大好机会。
Leveraging macrophage metabolism for anticancer therapy: opportunities and pitfalls.
Tumor-associated macrophages (TAMs) constitute an important part of the tumor microenvironment (TME) that regulates tumor progression. Tumor-derived signals, hypoxia, and competition for nutrients influence TAMs to reprogram their cellular metabolism. This altered metabolic profile creates a symbiotic communication between tumor and other immune cells to support tumor growth. In addition, the metabolic profile of TAMs regulates the expression of immune checkpoint molecules. The dynamic plasticity also allows TAMs to reshape their metabolism in response to modern therapeutic strategies. Therefore, over the years, a significant number of approaches have been implicated to reprogram cancer-promoting metabolism in TAMs. In this review, we discuss the current strategies and pitfalls, along with upcoming promising opportunities in leveraging TAM metabolism for developing better therapeutic approaches against cancer.
期刊介绍:
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.