Marjolein M van Vliet, Sam Schoenmakers, Joost Gribnau, Régine P M Steegers-Theunissen
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Next, results are discussed per study approach: (1) global DNA methylation (<i>n</i> = 9), (2) genome-wide analyses (<i>n</i> = 4), and (3) gene specific (<i>n</i> = 14). Generally, one-carbon moieties were not associated with global methylation, although conflicting outcomes were reported specifically for choline. Using genome-wide approaches, few differentially methylated sites associated with S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), or dietary patterns. Most studies taking a gene-specific approach indicated site-specific relationships depending on studied moiety and genomic region, specifically in genes involved in growth and development including <i>LEP</i>, <i>NR3C1, CRH</i>, and <i>PlGF</i>; however, overlap between studies was low. 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Using genome-wide approaches, few differentially methylated sites associated with S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), or dietary patterns. Most studies taking a gene-specific approach indicated site-specific relationships depending on studied moiety and genomic region, specifically in genes involved in growth and development including <i>LEP</i>, <i>NR3C1, CRH</i>, and <i>PlGF</i>; however, overlap between studies was low. 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引用次数: 0
摘要
表观遗传修饰(包括 DNA 甲基化)是解释父母对胎儿发育和终生健康的影响的拟议机制。叶酸、胆碱和维生素 B12 等微量营养素为一碳代谢和随后的 DNA 甲基化过程提供甲基。胎盘 DNA 甲基化对一碳分子的反应变化是改善产科护理的潜在目标。我们对一碳代谢与人类胎盘 DNA 甲基化之间的关系进行了系统回顾。我们纳入了 22 项研究。针对不同的一碳分子,我们总结了 ErasmusAGE 质量分数最低为 5/10 的临床研究(n = 15)和体外研究(n = 3)的结果。接下来讨论了每种研究方法的结果:(1)全局 DNA 甲基化(n = 9),(2)全基因组分析(n = 4),(3)特定基因(n = 14)。一般来说,单碳分子与全局甲基化无关,但针对胆碱的分析结果却相互矛盾。利用全基因组方法,与 S-腺苷蛋氨酸(SAM)、S-腺苷高半胱氨酸(SAH)或饮食模式相关的不同甲基化位点很少。大多数采用基因特异性方法的研究表明,根据所研究的分子和基因组区域,特别是在涉及生长和发育的基因(包括 LEP、NR3C1、CRH 和 PlGF)中,存在特定的位点关系;但是,不同研究之间的重叠率很低。因此,我们建议进一步研究优化的一碳代谢对 DNA 甲基化和终身健康的影响。
The one-carbon metabolism as an underlying pathway for placental DNA methylation - a systematic review.
Epigenetic modifications, including DNA methylation, are proposed mechanisms explaining the impact of parental exposures to foetal development and lifelong health. Micronutrients including folate, choline, and vitamin B12 provide methyl groups for the one-carbon metabolism and subsequent DNA methylation processes. Placental DNA methylation changes in response to one-carbon moieties hold potential targets to improve obstetrical care. We conducted a systematic review on the associations between one-carbon metabolism and human placental DNA methylation. We included 22 studies. Findings from clinical studies with minimal ErasmusAGE quality score 5/10 (n = 15) and in vitro studies (n = 3) are summarized for different one-carbon moieties. Next, results are discussed per study approach: (1) global DNA methylation (n = 9), (2) genome-wide analyses (n = 4), and (3) gene specific (n = 14). Generally, one-carbon moieties were not associated with global methylation, although conflicting outcomes were reported specifically for choline. Using genome-wide approaches, few differentially methylated sites associated with S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), or dietary patterns. Most studies taking a gene-specific approach indicated site-specific relationships depending on studied moiety and genomic region, specifically in genes involved in growth and development including LEP, NR3C1, CRH, and PlGF; however, overlap between studies was low. Therefore, we recommend to further investigate the impact of an optimized one-carbon metabolism on DNA methylation and lifelong health.
期刊介绍:
Epigenetics publishes peer-reviewed original research and review articles that provide an unprecedented forum where epigenetic mechanisms and their role in diverse biological processes can be revealed, shared, and discussed.
Epigenetics research studies heritable changes in gene expression caused by mechanisms others than the modification of the DNA sequence. Epigenetics therefore plays critical roles in a variety of biological systems, diseases, and disciplines. Topics of interest include (but are not limited to):
DNA methylation
Nucleosome positioning and modification
Gene silencing
Imprinting
Nuclear reprogramming
Chromatin remodeling
Non-coding RNA
Non-histone chromosomal elements
Dosage compensation
Nuclear organization
Epigenetic therapy and diagnostics
Nutrition and environmental epigenetics
Cancer epigenetics
Neuroepigenetics