{"title":"确定 KLOTHO 和 ARNTL 基因的 DNA 甲基化状态与高血压的关系","authors":"M Osum, O Tosun, H Birtan, R Kalkan","doi":"10.2478/bjmg-2023-0024","DOIUrl":null,"url":null,"abstract":"<p><p>Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. <i>KLOTHO</i> and <i>ARNTL</i> genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of <i>KLOTHO</i> and <i>ARNTL</i> genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between <i>KLOTHO</i> and <i>ARNTL</i> methylation and the hypertensive phenotype. Moreover, we could not find a direct association between <i>KLOTHO</i> and <i>ARNTL</i> methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated <i>KLOTHO</i> hypertensive patients and the unmethylated <i>KLOTHO</i> control subjects for potassium (K).</p>","PeriodicalId":55403,"journal":{"name":"Balkan Journal of Medical Genetics","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932598/pdf/","citationCount":"0","resultStr":"{\"title\":\"Determination of the Relationship Between DNA Methylation Status of <i>KLOTHO</i> and <i>ARNTL</i> Genes With Hypertension.\",\"authors\":\"M Osum, O Tosun, H Birtan, R Kalkan\",\"doi\":\"10.2478/bjmg-2023-0024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. <i>KLOTHO</i> and <i>ARNTL</i> genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of <i>KLOTHO</i> and <i>ARNTL</i> genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between <i>KLOTHO</i> and <i>ARNTL</i> methylation and the hypertensive phenotype. Moreover, we could not find a direct association between <i>KLOTHO</i> and <i>ARNTL</i> methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated <i>KLOTHO</i> hypertensive patients and the unmethylated <i>KLOTHO</i> control subjects for potassium (K).</p>\",\"PeriodicalId\":55403,\"journal\":{\"name\":\"Balkan Journal of Medical Genetics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-03-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932598/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Balkan Journal of Medical Genetics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2478/bjmg-2023-0024\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Balkan Journal of Medical Genetics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2478/bjmg-2023-0024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Determination of the Relationship Between DNA Methylation Status of KLOTHO and ARNTL Genes With Hypertension.
Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. KLOTHO and ARNTL genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of KLOTHO and ARNTL genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between KLOTHO and ARNTL methylation and the hypertensive phenotype. Moreover, we could not find a direct association between KLOTHO and ARNTL methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated KLOTHO hypertensive patients and the unmethylated KLOTHO control subjects for potassium (K).
期刊介绍：
Balkan Journal of Medical Genetics is a journal in the English language for publication of articles involving all branches of medical genetics: human cytogenetics, molecular genetics, clinical genetics, immunogenetics, oncogenetics, pharmacogenetics, population genetics, genetic screening and diagnosis of monogenic and polygenic diseases, prenatal and preimplantation genetic diagnosis, genetic counselling, advances in treatment and prevention.
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