通过靶向代谢推进胶质母细胞瘤的治疗

IF 4.8 2区 医学 Q1 Biochemistry, Genetics and Molecular Biology
Jinyi Zhao , Xuemei Ma , Peixian Gao , Xueqi Han , Pengxiang Zhao , Fei Xie , Mengyu Liu
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引用次数: 0

摘要

细胞代谢的改变是胶质母细胞瘤(GBM)的重要特征。代谢重编程是一个关键特征,因为它能满足肿瘤细胞更高的营养需求,包括增殖、生长和存活。许多与 GBM 代谢重编程相关的基因、蛋白质和代谢物被发现异常表达,这可能为癌症治疗提供潜在靶点。因此,探索内外因素在代谢调节中的作用以确定更精确的 GBM 治疗靶点和诊断标志物变得越来越重要。在这篇综述中,我们定义了 GBM 的代谢特征,研究了代谢的特异性,如可靶向的脆弱性和治疗耐药性,并介绍了目前针对 GBM 代谢以改善治疗标准的努力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advancing glioblastoma treatment by targeting metabolism

Alterations in cellular metabolism are important hallmarks of glioblastoma(GBM). Metabolic reprogramming is a critical feature as it meets the higher nutritional demand of tumor cells, including proliferation, growth, and survival. Many genes, proteins, and metabolites associated with GBM metabolism reprogramming have been found to be aberrantly expressed, which may provide potential targets for cancer treatment. Therefore, it is becoming increasingly important to explore the role of internal and external factors in metabolic regulation in order to identify more precise therapeutic targets and diagnostic markers for GBM. In this review, we define the metabolic characteristics of GBM, investigate metabolic specificities such as targetable vulnerabilities and therapeutic resistance, as well as present current efforts to target GBM metabolism to improve the standard of care.

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来源期刊
Neoplasia
Neoplasia 医学-肿瘤学
CiteScore
9.20
自引率
2.10%
发文量
82
审稿时长
26 days
期刊介绍: Neoplasia publishes the results of novel investigations in all areas of oncology research. The title Neoplasia was chosen to convey the journal’s breadth, which encompasses the traditional disciplines of cancer research as well as emerging fields and interdisciplinary investigations. Neoplasia is interested in studies describing new molecular and genetic findings relating to the neoplastic phenotype and in laboratory and clinical studies demonstrating creative applications of advances in the basic sciences to risk assessment, prognostic indications, detection, diagnosis, and treatment. In addition to regular Research Reports, Neoplasia also publishes Reviews and Meeting Reports. Neoplasia is committed to ensuring a thorough, fair, and rapid review and publication schedule to further its mission of serving both the scientific and clinical communities by disseminating important data and ideas in cancer research.
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