精神分裂症患者伽马波段听觉稳态反应受损背后的皮质白质微结构改变

IF 3 Q2 PSYCHIATRY
Daisuke Koshiyama, Ryoichi Nishimura, Kaori Usui, Mao Fujioka, Mariko Tada, Kenji Kirihara, Tsuyoshi Araki, Shintaro Kawakami, Naohiro Okada, Shinsuke Koike, Hidenori Yamasue, Osamu Abe, Kiyoto Kasai
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摘要

伽马波段听觉稳态反应(ASSR)主要由听觉皮层产生,作为精神分裂症病理生理学的潜在脑标记已受到广泛关注。以往的研究表明,精神分裂症患者的伽马波段听觉稳态反应减弱,并与神经认知和社会心理功能受损有关。最近在临床和健康人群中进行的研究表明,伽马波段ASSR降低的神经基底可能分布在听觉皮层周围的皮层中,尤其是右半球。本研究旨在调查伽马波段ASSR与广泛连接右侧额叶、顶叶和枕叶皮层的白质束改变之间的关联,以明确精神分裂症患者伽马波段ASSR降低的基础网络。我们使用脑电图和弥散张量成像技术测量了42名精神分裂症患者和22名健康对比受试者的40赫兹ASSR。结果显示,伽马波段 ASSR 与健康受试者右侧额叶、顶叶和枕叶皮层连接区域的分数各向异性(白质完整性指数)呈正相关(β = 0.41,校正后 p = 0.075,未校正 p = 0.038),但与精神分裂症患者无关(β = 0.17,校正后 p = 0.46,未校正 p = 0.23)。这些发现支持了我们的假设,即伽马波段 ASSR 的产生是由广泛连接大脑皮层的白质束支持的,而精神分裂症患者的这些关系可能会被破坏。我们的研究可能有助于描述和解释伽马波段ASSR的减少,并将其作为精神分裂症的一个有用的脑标记。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cortical white matter microstructural alterations underlying the impaired gamma-band auditory steady-state response in schizophrenia.

Cortical white matter microstructural alterations underlying the impaired gamma-band auditory steady-state response in schizophrenia.

The gamma-band auditory steady-state response (ASSR), primarily generated from the auditory cortex, has received substantial attention as a potential brain marker indicating the pathophysiology of schizophrenia. Previous studies have shown reduced gamma-band ASSR in patients with schizophrenia and demonstrated correlations with impaired neurocognition and psychosocial functioning. Recent studies in clinical and healthy populations have suggested that the neural substrates of reduced gamma-band ASSR may be distributed throughout the cortices surrounding the auditory cortex, especially in the right hemisphere. This study aimed to investigate associations between the gamma-band ASSR and white matter alterations in the bundles broadly connecting the right frontal, parietal and occipital cortices to clarify the networks underlying reduced gamma-band ASSR in patients with schizophrenia. We measured the 40 Hz ASSR using electroencephalography and diffusion tensor imaging in 42 patients with schizophrenia and 22 healthy comparison subjects. The results showed that the gamma-band ASSR was positively correlated with fractional anisotropy (an index of white matter integrity) in the regions connecting the right frontal, parietal and occipital cortices in healthy subjects (β = 0.41, corrected p = 0.075, uncorrected p = 0.038) but not in patients with schizophrenia (β = 0.17, corrected p = 0.46, uncorrected p = 0.23). These findings support our hypothesis that the generation of gamma-band ASSR is supported by white matter bundles that broadly connect the cortices and that these relationships may be disrupted in schizophrenia. Our study may help characterize and interpret reduced gamma-band ASSR as a useful brain marker of schizophrenia.

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