心房肌病的病理生理学和临床意义。

IF 7.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Basic Research in Cardiology Pub Date : 2024-04-01 Epub Date: 2024-03-12 DOI:10.1007/s00395-024-01038-0

Michiel R L Tubeeckx, Gilles W De Keulenaer, Hein Heidbuchel, Vincent F M Segers

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引用次数: 0

摘要

心房肌病是一种由心房的电学、结构、收缩和自主神经重塑组成的疾病，是最常见的心律失常--心房颤动的发病基础。导致心房肌病的病理生理机制包括炎症、氧化应激、心房拉伸和神经激素信号（如血管紧张素 II 和醛固酮）。这些机制启动了心房心肌的结构和功能重塑。目前正在针对心房肌病的病理生理机制开发新的治疗策略。在本综述中，我们将讨论心房肌病的病理生理学以及诊断和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pathophysiology and clinical relevance of atrial myopathy.

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Pathophysiology and clinical relevance of atrial myopathy.

Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria and is the substrate for development of atrial fibrillation, the most common arrhythmia. Pathophysiologic mechanisms driving atrial myopathy are inflammation, oxidative stress, atrial stretch, and neurohormonal signals, e.g., angiotensin-II and aldosterone. These mechanisms initiate the structural and functional remodeling of the atrial myocardium. Novel therapeutic strategies are being developed that target the pathophysiologic mechanisms of atrial myopathy. In this review, we will discuss the pathophysiology of atrial myopathy, as well as diagnostic and therapeutic strategies.

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来源期刊

Basic Research in Cardiology 医学-心血管系统

CiteScore

16.30

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Basic Research in Cardiology is an international journal for cardiovascular research. It provides a forum for original and review articles related to experimental cardiology that meet its stringent scientific standards. Basic Research in Cardiology regularly receives articles from the fields of - Molecular and Cellular Biology - Biochemistry - Biophysics - Pharmacology - Physiology and Pathology - Clinical Cardiology