ParTRE:帕金森病复杂实体和不平衡关系的三重关系提取模型。

IF 4 2区 医学 Q2 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
Xiaoming Zhang , Can Yu , Rui Yan
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引用次数: 0

摘要

从有关帕金森病的非结构化医学文本中提取三重关系对于构建医学知识图谱至关重要。然而,帕金森病的三元实体通常比较复杂且相互重叠,这阻碍了三元提取的准确性,尤其是在很少有可用语料的情况下。因此,本研究首先建立了一个有关帕金森病的语料库。然后,提出了一种基于标记的三阶段关系三元提取模型,命名为 ParTRE。为了增强句子的上下文表示,该模型采用了 BiLSTM 模块来捕捉细粒度语义信息。此外,还使用了条件归一化层,以便从两个互补的方向准确提取实体对。至于不平衡的关系类别,通过为关系类别分配不同权重和减少易分类样本的损失,得出了基于焦点损失的自适应损失函数策略。在帕金森语料库和公共数据集上对模型性能进行了评估。结果表明,所提出的模型在帕金森语料库中的总体 F1 分数达到了 93.3%,在公共数据集上的表现与最先进的方法相当。此外,该模型在处理重叠实体和不平衡关系类别方面也取得了令人满意的结果。由于所提出的方法具有可用性和有效性,因此可以与医学知识图谱相结合,从而为医学智能带来益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

ParTRE: A relational triple extraction model of complicated entities and imbalanced relations in Parkinson’s disease

ParTRE: A relational triple extraction model of complicated entities and imbalanced relations in Parkinson’s disease

The relational triple extraction of unstructured medical texts about Parkinson’s disease is critical for the construction of a medical knowledge graph. However, the triple entities in Parkinson’s disease are usually complicated and overlapped, which impedes the accuracy of triple extraction, especially in the case of rarely available corpus. Therefore, this study first builds a corpus about Parkinson’s disease. Then, a tagging-based three-stage relational triple extraction model is proposed, named ParTRE. To enhance the contextual representation of sentences, the proposed model employs BiLSTM modules to capture fine-grained semantic information. Additionally, a conditional normalization layer is used so that entity pairs can be extracted accurately from two complementary directions. As for the imbalanced relationship categories, an adaptive loss function strategy based on focal loss is derived by assigning different weights to relationship categories and reducing the loss of easy-to-classify samples. The model performance is evaluated on the Parkinson’s corpus and public datasets. The results indicate that the proposed model achieves an overall F1-score of 93.3 % on the Parkinson’s corpus and comparable performance on public datasets compared with the state-of-the-art methods. Moreover, a satisfactory result is achieved by the proposed model on conquering the overlapped entities and imbalanced relationship categories. Owing to demonstrated availability and validity, the proposed method can be integrated with medical knowledge graphs and therefore benefits medical intelligence.

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来源期刊
Journal of Biomedical Informatics
Journal of Biomedical Informatics 医学-计算机:跨学科应用
CiteScore
8.90
自引率
6.70%
发文量
243
审稿时长
32 days
期刊介绍: The Journal of Biomedical Informatics reflects a commitment to high-quality original research papers, reviews, and commentaries in the area of biomedical informatics methodology. Although we publish articles motivated by applications in the biomedical sciences (for example, clinical medicine, health care, population health, and translational bioinformatics), the journal emphasizes reports of new methodologies and techniques that have general applicability and that form the basis for the evolving science of biomedical informatics. Articles on medical devices; evaluations of implemented systems (including clinical trials of information technologies); or papers that provide insight into a biological process, a specific disease, or treatment options would generally be more suitable for publication in other venues. Papers on applications of signal processing and image analysis are often more suitable for biomedical engineering journals or other informatics journals, although we do publish papers that emphasize the information management and knowledge representation/modeling issues that arise in the storage and use of biological signals and images. System descriptions are welcome if they illustrate and substantiate the underlying methodology that is the principal focus of the report and an effort is made to address the generalizability and/or range of application of that methodology. Note also that, given the international nature of JBI, papers that deal with specific languages other than English, or with country-specific health systems or approaches, are acceptable for JBI only if they offer generalizable lessons that are relevant to the broad JBI readership, regardless of their country, language, culture, or health system.
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