D. A. Shergin, A. P. Iakovlev, P. V. Gorelkin, S. V. Salikhov, A. S. Erofeev
{"title":"用于串行条件下单细胞分析的扫描离子电导显微镜和纳米移液管系统的最新进展","authors":"D. A. Shergin, A. P. Iakovlev, P. V. Gorelkin, S. V. Salikhov, A. S. Erofeev","doi":"10.3103/S0027134923060152","DOIUrl":null,"url":null,"abstract":"<p>Studying single cells opens opportunities for understanding many biological processes and, as a consequence, plays an important role in the development of biomedicine. Scanning ion conductance microscopy (SICM) and nanopipette systems for the analysis of single cells represent a powerful tool for investigating the morphological, mechanical, and biochemical features of living cells with nanometer spatial resolution under near-natural conditions. Over the last decades, SICM has shown great success in studying and manipulating single cells, and the noncontact nature of the system, combined with the unique features of nanopipettes used as probes, has opened new possibilities for the application of such systems in biomedical applications. This review reflects the latest trends and directions in the development of SICM and nanopipette systems for the single-cell analysis.</p>","PeriodicalId":711,"journal":{"name":"Moscow University Physics Bulletin","volume":"78 6","pages":"729 - 743"},"PeriodicalIF":0.4000,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Latest Advances in Scanning Ion-Conductance Microscopy and Nanopipette Systems for Single-Cell Analysis under Serial Conditions\",\"authors\":\"D. A. Shergin, A. P. Iakovlev, P. V. Gorelkin, S. V. Salikhov, A. S. Erofeev\",\"doi\":\"10.3103/S0027134923060152\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Studying single cells opens opportunities for understanding many biological processes and, as a consequence, plays an important role in the development of biomedicine. Scanning ion conductance microscopy (SICM) and nanopipette systems for the analysis of single cells represent a powerful tool for investigating the morphological, mechanical, and biochemical features of living cells with nanometer spatial resolution under near-natural conditions. Over the last decades, SICM has shown great success in studying and manipulating single cells, and the noncontact nature of the system, combined with the unique features of nanopipettes used as probes, has opened new possibilities for the application of such systems in biomedical applications. This review reflects the latest trends and directions in the development of SICM and nanopipette systems for the single-cell analysis.</p>\",\"PeriodicalId\":711,\"journal\":{\"name\":\"Moscow University Physics Bulletin\",\"volume\":\"78 6\",\"pages\":\"729 - 743\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2024-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Moscow University Physics Bulletin\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.3103/S0027134923060152\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moscow University Physics Bulletin","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.3103/S0027134923060152","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
Latest Advances in Scanning Ion-Conductance Microscopy and Nanopipette Systems for Single-Cell Analysis under Serial Conditions
Studying single cells opens opportunities for understanding many biological processes and, as a consequence, plays an important role in the development of biomedicine. Scanning ion conductance microscopy (SICM) and nanopipette systems for the analysis of single cells represent a powerful tool for investigating the morphological, mechanical, and biochemical features of living cells with nanometer spatial resolution under near-natural conditions. Over the last decades, SICM has shown great success in studying and manipulating single cells, and the noncontact nature of the system, combined with the unique features of nanopipettes used as probes, has opened new possibilities for the application of such systems in biomedical applications. This review reflects the latest trends and directions in the development of SICM and nanopipette systems for the single-cell analysis.
期刊介绍：
Moscow University Physics Bulletin publishes original papers (reviews, articles, and brief communications) in the following fields of experimental and theoretical physics: theoretical and mathematical physics; physics of nuclei and elementary particles; radiophysics, electronics, acoustics; optics and spectroscopy; laser physics; condensed matter physics; chemical physics, physical kinetics, and plasma physics; biophysics and medical physics; astronomy, astrophysics, and cosmology; physics of the Earth’s, atmosphere, and hydrosphere.
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