B. Mando, A. Al Athamneh, B. Alkhawaja, C. Shannakian, A. Khaleel
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引用次数: 0
摘要
摘要 纳米粒子是当前科学发展的一个重要方面,在许多领域都有潜在的应用。特别是在伤口愈合等治疗领域,二氧化硅纳米粒子(SiNPs)独特的物理和化学特性引起了人们的关注。整合素亚基α V (ITGA-V)、整合素亚基α 5 (ITGA-5)、S100钙结合蛋白 A4 (S100A4) 和血管内皮生长因子 A (VEGFA)),以研究这些发现对更好的伤口愈合的影响,并更好地了解如何利用硅纳米粒子再生组织和修复伤口。我们的研究结果表明,二氧化硅纳米粒子可以通过上调这些参与伤口愈合过程的关键基因的表达,显著促进伤口愈合。
Investigating the Effect of Silica Nanoparticles on MMP9, HAS2, ITGAX, and Additional Key Genes: Implications for Enhanced Wound Healing
Abstract
Nanoparticles are an essential aspect of current scientific evolution, offering several potential applications in a number of fields. Particularly, in the therapeutic field such as in wound healing, the unique physical and chemical properties of silica nanoparticles (SiNPs) have attracted attention to it. In this study, we intend to investigate the relationship between silica nanoparticles and wound healing by analyzing altered gene expression before and after the treatment with (SiNPs), of 40 tissue repair related genes, giving special attention to (Matrix Metalloproteinase-9 (MMP-9), hyaluronan synthase 2 (HAS-2), integrin subunit alpha X (ITGA-X), integrin subunit alpha V (ITGA-V), integrin subunit alpha 5 (ITGA-5), S100 calcium binding protein A4 (S100A4), and vascular endothelial growth factor A (VEGFA)), to study the implications of these findings for better wound healing and to provide better insight into how SiNPs might be used to regenerate tissues and repair wounds. Our results showed that silica nanoparticles can significantly enhance wound healing by upregulating the expression of these key genes involved in the process.
期刊介绍:
Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.