日本酒精依赖男性的 ADH1B 和 ALDH2 基因型以及酒精潮红与饮酒史、戒断症状和 ICD-10 标准的关系。

IF 1.7 3区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Pharmacogenetics and genomics Pub Date : 2024-07-01 Epub Date: 2024-03-11 DOI:10.1097/FPC.0000000000000528
Akira Yokoyama, Tetsuji Yokoyama, Yosuke Yumoto, Tsuyoshi Takimura, Tomomi Toyama, Junichi Yoneda, Kotaro Nishimura, Ruriko Minobe, Takanobu Matsuzaki, Mitsuru Kimura, Sachio Matsushita
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引用次数: 0

摘要

研究目的鉴于快速代谢型酒精脱氢酶-1B*2(ADH1B*2)和非活性醛脱氢酶-2*2(ALDH2*2)等位基因在东亚人中的高流行率,我们评估了ADH1B/ALDH2基因型和酒精潮红如何影响酒精依赖(AD)的发展:我们评估了4116名日本男性酒精依赖症患者的ADH1B/ALDH2基因型和自我报告的酒精潮红对饮酒史、戒断症状和ICD-10标准的影响:在习惯性饮酒、停饮、白天饮酒、无节制饮酒、戒断症状和首次治疗AD的所有年龄以及当前年龄方面,ADH1B*1/*1组和ALDH2*1/*1组分别比ADH1B*2(+)组和ALDH2*1/*2组年轻1-5岁。在ADH1B*1/*1组和ALDH2*1/*1组中,停酒现象更为常见。在 ADH1B*1/*1 组中,白天饮酒、无节制饮酒和戒断症状(如手抖、出汗、抽搐和震颤性谵妄/幻觉)更为常见。ADH1B*1/*1 与 ICD-10 标准中的 "耐受性 "和 "戒断症状 "呈正相关。ADH1B*1/*1 组和 ALDH2*1/*2 组的 ICD-10 评分较高。ALDH2*1/*1和ALDH2*1/*2携带者中分别有91.7%和35.2%的人从未出现过潮红。在曾经/现在潮红组中,习惯性饮酒的开始时间延迟了1-2年后,上述饮酒里程碑的年龄没有因潮红状态的不同而出现差异:结论:ADH1B*1/*1和ALDH2*1/*1加速了日本AD患者饮酒事件和戒断症状的发展。ADH1B*1/*1 组和 ALDH2*1/*2 组的 ICD-10 评分更高。酒精潮红对饮酒事件的影响有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of ADH1B and ALDH2 genotypes and alcohol flushing with drinking history, withdrawal symptoms, and ICD-10 criteria in Japanese alcohol-dependent men.

Objectives: Given the high prevalence of fast-metabolizing alcohol dehydrogenase-1B*2 (ADH1B*2 ) and inactive aldehyde dehydrogenase-2*2 (ALDH2*2 ) alleles in East Asians, we evaluated how the ADH1B / ALDH2 genotypes and alcohol flushing might affect the development of alcohol dependence (AD).

Methods: We evaluated how the ADH1B / ALDH2 genotypes and self-reported alcohol flushing affected history of drinking events and withdrawal symptoms and ICD-10 criteria in 4116 Japanese AD men.

Results: The ADH1B*1/*1 group and ALDH2*1/*1 group were 1-5 years younger than the ADH1B*2 (+) and ALDH2*1/*2 groups, respectively, for all of the ages at onset of habitual drinking, blackouts, daytime drinking, uncontrolled drinking, withdrawal symptoms, and first treatment for AD, and the current age. Blackouts were more common in the ADH1B*1/*1 group and ALDH2*1/*1 group. Daytime drinking, uncontrolled drinking, and withdrawal symptoms, such as hand tremor, sweating, convulsions, and delirium tremens/hallucinations were more common in the ADH1B*1/*1 group. The ADH1B*1/*1 was positively associated with the ICD-10 criteria for 'tolerance' and 'withdrawal symptoms'. The ADH1B*1/*1 group and ALDH2*1/*2 group had a larger ICD-10 score. Never flushing was reported by 91.7% and 35.2% of the ALDH2*1/*1 and ALDH2*1/*2 carriers, respectively. After a 1-2-year delay in the onset of habitual drinking in the former-/current-flushing group, no differences in the ages of the aforementioned drinking milestones were found according to the flushing status.

Conclusion: The ADH1B*1/*1 and ALDH2*1/*1 accelerated the development of drinking events and withdrawal symptoms in Japanese AD patients. ICD-10 score was larger in the ADH1B*1/*1 group and ALDH2*1/*2 group. The effects of alcohol flushing on drinking events were limited.

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来源期刊
Pharmacogenetics and genomics
Pharmacogenetics and genomics 医学-生物工程与应用微生物
CiteScore
3.20
自引率
3.80%
发文量
47
审稿时长
3 months
期刊介绍: ​​​​Pharmacogenetics and Genomics is devoted to the rapid publication of research papers, brief review articles and short communications on genetic determinants in response to drugs and other chemicals in humans and animals. The Journal brings together papers from the entire spectrum of biomedical research and science, including biochemistry, bioinformatics, clinical pharmacology, clinical pharmacy, epidemiology, genetics, genomics, molecular biology, pharmacology, pharmaceutical sciences, and toxicology. Under a single cover, the Journal provides a forum for all aspects of the genetics and genomics of host response to exogenous chemicals: from the gene to the clinic.
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