根据放射性核素的核衰变特性选择用于α靶向治疗的放射性核素。

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear Medicine Communications Pub Date : 2024-06-01 Epub Date: 2024-03-11 DOI:10.1097/MNM.0000000000001832
Samantha M Ree, Howard Greenwood, Jennifer D Young, Rachel Roberts, Francis R Livens, Scott L Heath, Jane K Sosabowski
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引用次数: 0

摘要

靶向α疗法(TAT)是一种很有前景的肿瘤治疗方法,它利用的是α放射性核素,能在疾病部位特定地聚集。与α发射相关的高能量和高线性能量转移会对目标部位造成局部损伤,同时最大限度地减少对周围健康组织的损伤。缺乏合适的放射性核素阻碍了 TAT 研究。确定合适的放射性核素应主要考虑放射性核素的核衰变特性,而不是其生物化学或经济因素,因为后两个因素是可以改变的;但是,核衰变特性对于核素来说是固定不变的。本研究根据核衰变特性确定并应用了一个标准,该标准对技术评估有用。这项向下选择工作得出的结论是,最合适的放射性核素是149 Tb、211 At/ 211 Po、212 Pb/ 212 Bi/ 212 Po、213 Bi/ 213 Po、224 Ra、225 Ra/ 225 Ac/ 221 Fr、226 Ac/ 226 Th、227 Th/ 223 Ra/ 219 Rn、229 U、230 U/ 226 Th 和 253 Fm。229 U 和 253 Fm 是新发现的,根据它们的衰变链后代,可能会成为新的放射性核素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Selection of radionuclide(s) for targeted alpha therapy based on their nuclear decay properties.

Targeted alpha therapy (TAT) is a promising form of oncology treatment utilising alpha-emitting radionuclides that can specifically accumulate at disease sites. The high energy and high linear energy transfer associated with alpha emissions causes localised damage at target sites whilst minimising that to surrounding healthy tissue. The lack of appropriate radionuclides has inhibited research in TAT. The identification of appropriate radionuclides should be primarily a function of the radionuclide's nuclear decay properties, and not their biochemistry or economic factors since these last two factors can change; however, the nuclear decay properties are fixed to that nuclide. This study has defined and applied a criterion based on nuclear decay properties useful for TAT. This down-selection exercise concluded that the most appropriate radionuclides are: 149 Tb, 211 At/ 211 Po, 212 Pb/ 212 Bi/ 212 Po, 213 Bi/ 213 Po, 224 Ra, 225 Ra/ 225 Ac/ 221 Fr, 226 Ac/ 226 Th, 227 Th/ 223 Ra/ 219 Rn, 229 U, 230 U/ 226 Th, and 253 Fm, the majority of which have previously been considered for TAT. 229 U and 253 Fm have been newly identified and could become new radionuclides of interest for TAT, depending on their decay chain progeny.

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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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