治疗偏头痛的抗降钙素基因相关肽单克隆抗体:关注临床药代动力学。

IF 1.9 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Slobodan M Janković, Snežana V Janković
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引用次数: 0

摘要

降钙素基因相关肽传导是最近开发的有效预防发作性和慢性偏头痛药物的靶点。本综述旨在深入探讨获批用于预防偏头痛发作的单克隆抗体的药代动力学。本综述在MEDLINE和谷歌学术数据库中搜索了相关文献,时间跨度分别为1966-2023年和2006-2023年。此外,还在ClinicalTrials.gov数据库中搜索了2000-2023年间尚未在医学期刊上发表结果的相关临床研究。该组单克隆抗体主要分布在血浆和部分细胞外空间;既不在肝脏代谢,也不经肾脏排泄。galcanezumab、eptinezumab 和 fremanezumab 只通过肝脏中的网状内皮系统以非特异性线性过程排出体外,而 erenumab 则通过非特异性过程和特异性饱和过程排出体外,因为它们与细胞膜上的受体结合。由于消除过程的容量不大,艾伦单抗的半衰期约为 2 周,其他单克隆抗体的半衰期约为 4 周。这些单克隆抗体的药代动力学在不同亚群中的差异很小,体重是选择药物剂量时唯一需要考虑的参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Clinical Pharmacokinetics.

The calcitonin gene-related peptide transmission was the target for recent development of drugs that effectively prevent attacks of both episodic and chronic migraine. The aim of this narrative review was to offer deeper insight into pharmacokinetics of monoclonal antibodies approved for prevention of migraine attacks. For this narrative review, relevant literature was searched for in MEDLINE and Google Scholar databases, covering periods 1966-2023 and 2006-2023, respectively. The ClinicalTrials.gov database was also searched for relevant clinical studies whose results had not been published previously in medical journals, covering the period 2000-2023. The monoclonal antibodies from this group are distributed mainly in the plasma and part of the extracellular space; they are neither metabolized in the liver nor excreted via the kidneys. The elimination of galcanezumab, eptinezumab and fremanezumab takes place only by a non-specific linear process via the reticuloendothelial system in the liver, while erenumab is eliminated by a non-specific process and by a specific, saturable process because of binding to receptors located on the cell membrane. Since the elimination processes do not have a large capacity, the half-life is about 2 weeks for erenumab and about 4 weeks for other monoclonal antibodies. Variability in the pharmacokinetics of these monoclonal antibodies is small in different subpopulations, and body weight is the only parameter to consider when choosing the dose of these drugs.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
64
审稿时长
>12 weeks
期刊介绍: Hepatology International is a peer-reviewed journal featuring articles written by clinicians, clinical researchers and basic scientists is dedicated to research and patient care issues in hepatology. This journal focuses mainly on new and emerging diagnostic and treatment options, protocols and molecular and cellular basis of disease pathogenesis, new technologies, in liver and biliary sciences. Hepatology International publishes original research articles related to clinical care and basic research; review articles; consensus guidelines for diagnosis and treatment; invited editorials, and controversies in contemporary issues. The journal does not publish case reports.
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