成熟 B 细胞和 T 细胞淋巴瘤的基因改变--WHO-HAEM5 实用指南

IF 1.1 4区生物学

Medizinische Genetik Pub Date : 2024-03-04 DOI:10.1515/medgen-2024-2005

Cristina López, Anja Fischer, Andreas Rosenwald, R. Siebert, G. Ott, Katrin S. Kurz

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引用次数: 0

摘要

肿瘤细胞中复发性基因组改变的鉴定在成熟 B 细胞和 T 细胞淋巴瘤的分类中起着重要作用。随着新一代测序等新技术的发展以及传统细胞遗传学和分子细胞遗传学等经典技术的改进，淋巴肿瘤基因组改变的庞大目录已经建立。这些改变有助于完善淋巴瘤的分类，仔细研究不同淋巴瘤实体的鉴别诊断，并帮助评估患者的预后和临床治疗。因此，我们在此描述与成熟B细胞和T细胞淋巴瘤相关的关键基因改变。

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Genetic alterations in mature B- and T-cell lymphomas – a practical guide to WHO-HAEM5

The identification of recurrent genomic alterations in tumour cells has a significant role in the classification of mature B- and T-cell lymphomas. Following the development of new technologies, such as next generation sequencing and the improvement of classical technologies such as conventional and molecular cytogenetics, a huge catalogue of genomic alterations in lymphoid neoplasms has been established. These alterations are relevant to refine the taxonomy of the classification of lymphomas, to scrutinize the differential diagnosis within different lymphoma entities and to help assessing the prognosis and clinical management of the patients. Consequently, here we describe the key genetic alterations relevant in mature B- and T-cell lymphomas.

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来源期刊

Medizinische Genetik GENETICS & HEREDITY-

自引率

9.10%

发文量

期刊介绍： medizinischegenetik is a scientific journal that is owned and published by the German Society of Human Genetics e.V. since 1989. The journal was founded by Prof. Jan Murken, München. Self-published until 2006, from 2007-2019 published at Springer Verlag and since 2020 at De Gruyter. medizinischegenetik serves education and training among colleagues, the interdisciplinary exchange of knowledge in all areas of human genetics in clinics, practice, research and teaching. Each issue of the quarterly journal deals with a focus that provides a comprehensive overview of current developments in specific clinical pictures, technical developments and therapeutic approaches. All reviews are written in English language. The journal thus creates a platform for the international exchange of knowledge and increased awareness of German research activities in the scientific community. In addition, medizinischegenetik contains information on activities in its own subject in the German-language section. This includes conference reports, association announcements, personnel matters, statements and guidelines. With health policy questions, historical retrospectives and comments on current developments, the profession takes a stand on human genetic issues in Germany, Austria and Switzerland.