皮肤镜评估外用类固醇激素和窄带紫外线 B 联合治疗的perstans 失色性红斑:病例报告

Aisha Triani, Satya Wydya, Yenny
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摘要

背景:皮肤色素沉着性红斑(EDP)又称灰白皮肤病,是一种不常见的获得性顽固皮肤病,患者躯干、面部和四肢会出现大小不等的色素沉着斑。它的确切病因尚不清楚,治疗方法也一直存在争议。皮肤镜评估可能有助于评估治疗干预措施的效果。病例介绍:我们介绍了一例 20 岁女性的病例,她在过去三年里在躯干上部、腹部、背部和四肢出现了许多棕色至板岩灰色的色素沉着斑。患者称没有瘙痒、麻木或疼痛等症状。经体格检查,患者有轻度贫血,但身体健康。体格检查结果显示,患者全身多处出现大小不等、边界淡红的棕灰色斑块,粘膜、头皮、手掌、足底和指甲未受影响。皮肤镜检查显示,棕色至灰色背景广泛分布,外观呈粉红色均质。组织病理学检查结果显示为红斑色素沉着症。患者被确诊为 "perstans褪色红斑",并接受了外用类固醇激素和铌紫外线联合治疗,每周三次,持续 8 周。结论这种疾病会影响患者一生的容貌,严重影响他们的生活质量。外用类固醇激素和铌紫外线联合治疗 8 周后,红斑有所改善,皮损颜色也变浅了。这一观察结果表明,目前还没有一种治疗方法能持续取得良好效果,因此有必要进行进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dermoscopy Evaluation of Erythema Dyschromicum Perstans Treated with Combination of Topical Steroid and Narrowband-Ultraviolet B: A Case Report
Background: Erythema dyschromicum perstans (EDP), also known as ashy dermatosis, is an uncommon, acquired, and persistent skin condition identified by development of hyperpigmented macules of varying sizes on the trunk, face, and extremities. It exact cause is unknown, and there is ongoing debate surrounding its treatment. Dermoscopic assessments may prove beneficial in evaluating the effectiveness of therapeutic interventions. Case presentation: We present a case of a 20-year-old woman with numerous hyperpigmented macules of brown to slate-grey on her upper trunk, stomach, back, and extremities over the past three years. The patient reported no symptoms such as itching, numbness, or pain. Upon physical examination, mild anemia but otherwise healthy. On physical examination there are multiple brown-grey patches with reddish borders of varying sizes distributed across the body, with unaffected mucosa, scalp, palms, soles, and nails. Dermoscopic examination unveiled a widespread distribution of brown to grey backgrounds with a pinkish homogeneous appearance. Histopathological examination suitable for erythema dyschromicum perstans. The patient received a diagnosis of erythema dyschromicum perstans and underwent treatment involving a combination of topical steroids and Nb-UVB administered three times weekly for a duration of 8 weeks. Conclusion: This condition presents a cosmetic concern throughout the patient's lifetime and significantly affects their quality of life. After 8 weeks of the combination of topical steroids and Nb-UVB, there was a improvement of erythema and lesion appear lighter. This observation suggests that a treatment with a consistently favorable outcome has not been identified and necessitates further investigation.
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