基于图像细胞测量的不同 DNA 倍性模式对子宫内膜癌的影响

Pub Date : 2024-02-01 DOI:10.3103/s0095452724010092

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引用次数: 0

摘要

摘要在世界范围内，子宫内膜癌是妇女最常诊断出的恶性肿瘤之一，也是导致妇女死亡的一个重要原因。本研究旨在对子宫内膜腺癌的前瞻性材料进行图像细胞学 DNA 倍性分析，以确定倍性状态与其组织学特征之间的潜在相关性。分析是在一系列患者（n = 126）实施全子宫切除术后切除的新鲜组织样本中进行的。我们发现，使用图像细胞仪检测的倍性状态与子宫内膜癌的组织学类型、分级和分期相关，非整倍体肿瘤样本与侵袭性表型统计相关。此外，在常规临床实践中，DNA 倍性应作为一种可靠、适用的预后标志物。

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Impact of Different DNA Ploidy Patterns on Endometrial Carcinomas Based on Image Cytometry

Abstract

Worldwide, endometrial cancer is one of the most frequently diagnosed malignancies in women and a notable cause of death. The aim of this study was to perform image cytometric DNA ploidy analysis on a prospective material of endometrial adenocarcinomas in order to determine potential correlation between ploidy status and their histological features. The analysis was carried out in fresh tissue samples resected by implementing complete hysterectomy in a series of patients (n = 126). We found that ploidy status using image cytometry correlate with histologic type, grade and stage in endometrial cancer and aneuploid tumor samples are associated with aggressive phenotype statistics. Furthermore, DNA ploidy should be used as a reliable and applicable prognostic marker in the routine clinical practice.

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