Seroprevalence of toxoplasmosis among children with autism

Toxoplasmosis is considered one of the most common public health troubles. Among these health troubles, toxoplasmosis was recently linked to many neuropsychiatric and behavioral disorders, especially autism spectrum disorder (ASD). The purpose of this study was to determine the seroprevalence of toxoplasmosis in children with ASD. The study was conducted on 100 children, grouped in two groups; group 1 (patient group) included 50 children with ASD and group 2 (control group) included 50 healthy children. ASD in the patient group was diagnosed according to DSM 5 criteria of ASD. Every child involved in this study underwent a history taking, a clinical examination, and laboratory investigations to detect serum anti-Toxoplasma IgG and IgM antibodies using ELISA. Children of the patient group were further assessed using the Childhood Autism Rating Scale to evaluate the severity of their symptoms. The seroprevalence of IgG among ASD children was highly significant compared to the healthy children. The detected difference between the 2 groups regarding seroprevalence of anti-Toxoplasma IgM antibodies was insignificant. No significant correlation could be demonstrated between Toxoplasma infection and severity of autistic symptoms in the ASD group. Furthermore, the study revealed an increase in anti-Toxoplasma IgG antibodies in ASD children with positive family history of ASD rather than those with no such history. In addition, an increase in seroprevalence of both anti-Toxoplasma antibodies among children with low socioeconomic standards compared to children with moderate or high standards. The study revealed that the old but not the recent infection with Toxoplasma in children could be linked to their ASD.