使用聚合物支撑的 PPh3/CBr4 作为试剂，从 N-Boc 保护的氨基酸衍生酰胺合成海因

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-03-09 DOI:10.1002/jhet.4802

Gordana Tasic, Nikola Mitrovic, Milena Simic, Mladen Koravovic, Predrag Jovanovic, Milos Petkovic, Milos Jovanovic, Branka Ivkovic, Vladimir Savic

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引用次数: 0

摘要

海因衍生物是天然产物和各种具有不同生物或其他特性的化合物中的多功能结构基团。由于它们在有机化学和药物化学中的重要性，人们开发了许多合成程序。本文介绍了一种利用 N-Boc 保护的氨基酸酰胺来制备它们的新方法。使用固体支持的 PPh3 和 CBr4 作为试剂完成了环化过程，以中等至良好的收率（40%-77%）得到了取代的海因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of hydantoins from N-Boc protected amino acid derived amides using polymer-supported PPh3/CBr4 as a reagent

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Synthesis of hydantoins from N-Boc protected amino acid derived amides using polymer-supported PPh3/CBr4 as a reagent

Hydantoin derivatives are versatile structural motifs found in natural products and various compounds with different biological or other properties. Due to their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology utilizing N-Boc protected amino acid amides for their preparation has been described. The cyclisation process was accomplished using solid supported PPh₃ and CBr₄ as reagents affording substituted hydantoins in moderate to good yields (40%–77%).

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.