Arlette Rodríguez-Campos , María N. Sánchez-Rivera , Jorge H. Luna-Domínguez , Clara C. Sánchez-Rodríguez
{"title":"血液透析患者的慢性肝损伤。分子检测对检测高危人群中隐性致肝病毒感染的重要性","authors":"Arlette Rodríguez-Campos , María N. Sánchez-Rivera , Jorge H. Luna-Domínguez , Clara C. Sánchez-Rodríguez","doi":"10.1016/j.aohep.2024.101412","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction and Objectives</h3><p>Worldwide, cirrhosis secondary to the hepatitis C virus is the first indication for liver transplantation. In Mexico, alcohol abuse, viral hepatitis, and obesity are the highlighted causes. Hepatitis C virus (HCV) eradication leads to reduced morbidity, mortality and transmission. Hemodialysis users are a high-risk group with high prevalence of HCV. The aim of this study was to identify patients with liver damage in hemodialysis users and their relationship with viral hepatitis, diagnosis, and management.</p></div><div><h3>Materials and Patients</h3><p>We reviewed the electronic medical records of hemodialysis users from January 1, 2017, to December 31, 2019. All patients who underwent at least one hemodialysis procedure were included. We used descriptive statistics with the SPSS v21 program.</p></div><div><h3>Results</h3><p>We analyzed 362 patients, 57% of whom were men, with a mean age of 52. The most frequent etiology attributable to kidney damage was hypertension 96% and diabetes mellitus 59%. The mean time on hemodialysis was 19 months. The biochemical and serological characteristics of the group are show in Table 1. We found forty-seven patients with transaminasemia, of which thirteen had liver cirrhosis, evaluated by FIB4/APRI. A viral load was requested for hepatitis C in only one patient, with a positive result, who received treatment with glecaprevir/pibrentasvir for 12 weeks without complications. Retrospective review limits us in identifying the cause for which the patients did not undergo molecular tests for hepatitis B and C. These patients have significant depression of immunity with negative serology on the presence of viral replication “hidden infection.”</p></div><div><h3>Conclusions</h3><p>Hemodialysis users should be exhaustively studied, and molecular tests should be performed on suspicion of viral hepatitis.</p></div>","PeriodicalId":7979,"journal":{"name":"Annals of hepatology","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1665268124002060/pdfft?md5=b9ad90f642f69975b0e7c7c224e655a2&pid=1-s2.0-S1665268124002060-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Chronic liver damage in hemodialysis users. The importance of molecular tests for detection of hidden infection by hepatotropic viruses in high-risk groups\",\"authors\":\"Arlette Rodríguez-Campos , María N. Sánchez-Rivera , Jorge H. Luna-Domínguez , Clara C. Sánchez-Rodríguez\",\"doi\":\"10.1016/j.aohep.2024.101412\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction and Objectives</h3><p>Worldwide, cirrhosis secondary to the hepatitis C virus is the first indication for liver transplantation. In Mexico, alcohol abuse, viral hepatitis, and obesity are the highlighted causes. Hepatitis C virus (HCV) eradication leads to reduced morbidity, mortality and transmission. Hemodialysis users are a high-risk group with high prevalence of HCV. The aim of this study was to identify patients with liver damage in hemodialysis users and their relationship with viral hepatitis, diagnosis, and management.</p></div><div><h3>Materials and Patients</h3><p>We reviewed the electronic medical records of hemodialysis users from January 1, 2017, to December 31, 2019. All patients who underwent at least one hemodialysis procedure were included. We used descriptive statistics with the SPSS v21 program.</p></div><div><h3>Results</h3><p>We analyzed 362 patients, 57% of whom were men, with a mean age of 52. The most frequent etiology attributable to kidney damage was hypertension 96% and diabetes mellitus 59%. The mean time on hemodialysis was 19 months. The biochemical and serological characteristics of the group are show in Table 1. We found forty-seven patients with transaminasemia, of which thirteen had liver cirrhosis, evaluated by FIB4/APRI. A viral load was requested for hepatitis C in only one patient, with a positive result, who received treatment with glecaprevir/pibrentasvir for 12 weeks without complications. Retrospective review limits us in identifying the cause for which the patients did not undergo molecular tests for hepatitis B and C. These patients have significant depression of immunity with negative serology on the presence of viral replication “hidden infection.”</p></div><div><h3>Conclusions</h3><p>Hemodialysis users should be exhaustively studied, and molecular tests should be performed on suspicion of viral hepatitis.</p></div>\",\"PeriodicalId\":7979,\"journal\":{\"name\":\"Annals of hepatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1665268124002060/pdfft?md5=b9ad90f642f69975b0e7c7c224e655a2&pid=1-s2.0-S1665268124002060-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of hepatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1665268124002060\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of hepatology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1665268124002060","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Chronic liver damage in hemodialysis users. The importance of molecular tests for detection of hidden infection by hepatotropic viruses in high-risk groups
Introduction and Objectives
Worldwide, cirrhosis secondary to the hepatitis C virus is the first indication for liver transplantation. In Mexico, alcohol abuse, viral hepatitis, and obesity are the highlighted causes. Hepatitis C virus (HCV) eradication leads to reduced morbidity, mortality and transmission. Hemodialysis users are a high-risk group with high prevalence of HCV. The aim of this study was to identify patients with liver damage in hemodialysis users and their relationship with viral hepatitis, diagnosis, and management.
Materials and Patients
We reviewed the electronic medical records of hemodialysis users from January 1, 2017, to December 31, 2019. All patients who underwent at least one hemodialysis procedure were included. We used descriptive statistics with the SPSS v21 program.
Results
We analyzed 362 patients, 57% of whom were men, with a mean age of 52. The most frequent etiology attributable to kidney damage was hypertension 96% and diabetes mellitus 59%. The mean time on hemodialysis was 19 months. The biochemical and serological characteristics of the group are show in Table 1. We found forty-seven patients with transaminasemia, of which thirteen had liver cirrhosis, evaluated by FIB4/APRI. A viral load was requested for hepatitis C in only one patient, with a positive result, who received treatment with glecaprevir/pibrentasvir for 12 weeks without complications. Retrospective review limits us in identifying the cause for which the patients did not undergo molecular tests for hepatitis B and C. These patients have significant depression of immunity with negative serology on the presence of viral replication “hidden infection.”
Conclusions
Hemodialysis users should be exhaustively studied, and molecular tests should be performed on suspicion of viral hepatitis.
期刊介绍:
Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.