{"title":"雕琢护理复原力：在嵌合抗原受体 T 细胞疗法中改变生命、培育伦理","authors":"Pranay Bende","doi":"10.1002/ctd2.283","DOIUrl":null,"url":null,"abstract":"<p>Revolutionizing cancer care, chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy anticancer treatment that uses genetically modified T-cells to combat cancer. Nurses have a key role in fostering resilience in patients and caregivers undergoing this therapy, and in navigating ethical and legal issues and safeguarding their rights and interests. Unlike haematological malignancies, solid tumours have more diverse and heterogeneous tumour-associated antigens (TAAs), which can lead to off-target toxicity or antigen escape.<span><sup>1</sup></span></p><p>Resilience enables the adversity to rebound from stress and trauma even amid faced with uncertainties risks and side effects including cytokine release syndrome, hypogammaglobulinemia, neurotoxicity, infection, prolonged cytopenias, and organ damage, and can lead to life-threatening in some cases (See Figure 1).</p><p>Mr. Bende contributed to preparing and collecting original literature and figures and writing and editing the manuscript.</p><p>The author declares no conflict of interest.</p><p>Not applicable.</p>","PeriodicalId":72605,"journal":{"name":"Clinical and translational discovery","volume":"4 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ctd2.283","citationCount":"0","resultStr":"{\"title\":\"Sculpting nursing resilience: Transforming lives, nurturing ethics in chimeric antigen receptor T-cell therapy\",\"authors\":\"Pranay Bende\",\"doi\":\"10.1002/ctd2.283\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Revolutionizing cancer care, chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy anticancer treatment that uses genetically modified T-cells to combat cancer. Nurses have a key role in fostering resilience in patients and caregivers undergoing this therapy, and in navigating ethical and legal issues and safeguarding their rights and interests. Unlike haematological malignancies, solid tumours have more diverse and heterogeneous tumour-associated antigens (TAAs), which can lead to off-target toxicity or antigen escape.<span><sup>1</sup></span></p><p>Resilience enables the adversity to rebound from stress and trauma even amid faced with uncertainties risks and side effects including cytokine release syndrome, hypogammaglobulinemia, neurotoxicity, infection, prolonged cytopenias, and organ damage, and can lead to life-threatening in some cases (See Figure 1).</p><p>Mr. Bende contributed to preparing and collecting original literature and figures and writing and editing the manuscript.</p><p>The author declares no conflict of interest.</p><p>Not applicable.</p>\",\"PeriodicalId\":72605,\"journal\":{\"name\":\"Clinical and translational discovery\",\"volume\":\"4 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ctd2.283\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and translational discovery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ctd2.283\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and translational discovery","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ctd2.283","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
嵌合抗原受体（CAR）T 细胞疗法是一种利用转基因 T 细胞抗击癌症的免疫抗癌疗法，它为癌症治疗带来了革命性的变化。护士在培养接受这种疗法的患者和护理人员的适应能力、处理伦理和法律问题以及维护他们的权益方面发挥着关键作用。与血液恶性肿瘤不同，实体瘤的肿瘤相关抗原（TAAs）更加多样化和异质性，这可能导致脱靶毒性或抗原逃逸。复原力使逆境中的人能够从压力和创伤中反弹，即使面临不确定的风险和副作用，包括细胞因子释放综合征、低丙种球蛋白血症、神经毒性、感染、长期细胞减少症和器官损伤，在某些情况下可能导致生命危险（见图1）。
Revolutionizing cancer care, chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy anticancer treatment that uses genetically modified T-cells to combat cancer. Nurses have a key role in fostering resilience in patients and caregivers undergoing this therapy, and in navigating ethical and legal issues and safeguarding their rights and interests. Unlike haematological malignancies, solid tumours have more diverse and heterogeneous tumour-associated antigens (TAAs), which can lead to off-target toxicity or antigen escape.1
Resilience enables the adversity to rebound from stress and trauma even amid faced with uncertainties risks and side effects including cytokine release syndrome, hypogammaglobulinemia, neurotoxicity, infection, prolonged cytopenias, and organ damage, and can lead to life-threatening in some cases (See Figure 1).
Mr. Bende contributed to preparing and collecting original literature and figures and writing and editing the manuscript.
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