灵长类离线经颅超声波刺激诱导的早期神经可塑性

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences Pub Date : 2024-03-08 DOI:10.1016/j.cobeha.2024.101370

Nadège Bault , Siti N Yaakub , Elsa Fouragnan

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引用次数: 0

摘要

在快速发展的低强度经颅超声刺激（TUS）领域，"离线 "经颅超声刺激（TUS）方案的使用尤其引人关注。离线 TUS 可在刺激后数小时内调节神经活动，从而诱导早期阶段的神经可塑性。在人类和非人灵长类动物身上进行的研究显示，神经调控目标以及与之相关的分布式区域网络都发生了空间特异性变化。这些变化表明，兴奋或抑制作用是所用方案与潜在脑区和状态之间复杂互动的结果。了解离线 TUS 如何诱导早期阶段的神经可塑性，可以为影响晚期阶段的神经可塑性和广泛的脑部疾病治疗应用开辟道路。

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Early-phase neuroplasticity induced by offline transcranial ultrasound stimulation in primates

The use of ‘offline’ transcranial ultrasound stimulation (TUS) protocols is of particular interest in the rapidly growing field of low-intensity TUS. Offline TUS can modulate neural activity up to several hours after stimulation, suggesting the induction of early-phase neuroplasticity. Studies in both humans and nonhuman primates have shown spatially specific changes in both the neuromodulation target and in a distributed network of regions associated with it. These changes suggest that excitatory or inhibitory effects are a result of a complex interaction between the protocol used and the underlying brain region and state. Understanding how early-phase neuroplasticity is induced by offline TUS could open avenues for influencing late-phase neuroplasticity and therapeutic applications in a wide range of brain disorders.

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来源期刊

Current Opinion in Behavioral Sciences Neuroscience-Cognitive Neuroscience

CiteScore

10.90

自引率

2.00%

发文量

135

期刊介绍： Current Opinion in Behavioral Sciences is a systematic, integrative review journal that provides a unique and educational platform for updates on the expanding volume of information published in the field of behavioral sciences.