油辣木叶乙醇提取物可对抗氯化铝诱导的大鼠大脑皮层神经变性。

IF 2.2 4区 医学 Q3 TOXICOLOGY
Toxicology Research Pub Date : 2024-03-05 eCollection Date: 2024-04-01 DOI:10.1093/toxres/tfae028
Rabab Fawzy Hindawy, Samia M Manawy, Ola Elsayed Nafea, Abeer A Abdelhameed, Fatma Fawzi Hendawi
{"title":"油辣木叶乙醇提取物可对抗氯化铝诱导的大鼠大脑皮层神经变性。","authors":"Rabab Fawzy Hindawy, Samia M Manawy, Ola Elsayed Nafea, Abeer A Abdelhameed, Fatma Fawzi Hendawi","doi":"10.1093/toxres/tfae028","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. <i>Moringa oleifera</i> (<i>M. oleifera</i>), known as a miracle tree, is utilized as a functional food and nutritional supplement. This study investigates the potential preventive effects of <i>M. oleifera</i> extract on aluminum chloride (AlCl3)-induced cortical neurodegeneration in rats.</p><p><strong>Materials and methods: </strong>Therefore, 24 adult male Wistar rats were randomly divided into four distinct groups: negative control, <i>M. oleifera</i> extract (MOE), AlCl3, and AlCl3 + MOE. Treatments were administered orally for 28 consecutive days. Cognitive performance, brain oxidative/nitrosative stress, neuroinflammation, apoptotic-cell death, and associated histopathological alterations were assessed.</p><p><strong>Results: </strong>Our results showed that MOE improved spatial learning and memory, enhanced antioxidant superoxide dismutase enzyme activity, antagonized nitrosative stress, reduced inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), decreased caspase-3, increased Bcl-2, and facilitated repair of cortical and hippocampal structures.</p><p><strong>Conclusions: </strong>We concluded that MOE exhibits protective effects against cortical neurodegeneration, making it a promising supplement to counteract aluminum-induced neurotoxic effects.</p>","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917235/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Moringa oleifera</i> leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats.\",\"authors\":\"Rabab Fawzy Hindawy, Samia M Manawy, Ola Elsayed Nafea, Abeer A Abdelhameed, Fatma Fawzi Hendawi\",\"doi\":\"10.1093/toxres/tfae028\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. <i>Moringa oleifera</i> (<i>M. oleifera</i>), known as a miracle tree, is utilized as a functional food and nutritional supplement. This study investigates the potential preventive effects of <i>M. oleifera</i> extract on aluminum chloride (AlCl3)-induced cortical neurodegeneration in rats.</p><p><strong>Materials and methods: </strong>Therefore, 24 adult male Wistar rats were randomly divided into four distinct groups: negative control, <i>M. oleifera</i> extract (MOE), AlCl3, and AlCl3 + MOE. Treatments were administered orally for 28 consecutive days. Cognitive performance, brain oxidative/nitrosative stress, neuroinflammation, apoptotic-cell death, and associated histopathological alterations were assessed.</p><p><strong>Results: </strong>Our results showed that MOE improved spatial learning and memory, enhanced antioxidant superoxide dismutase enzyme activity, antagonized nitrosative stress, reduced inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), decreased caspase-3, increased Bcl-2, and facilitated repair of cortical and hippocampal structures.</p><p><strong>Conclusions: </strong>We concluded that MOE exhibits protective effects against cortical neurodegeneration, making it a promising supplement to counteract aluminum-induced neurotoxic effects.</p>\",\"PeriodicalId\":105,\"journal\":{\"name\":\"Toxicology Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917235/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/toxres/tfae028\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/toxres/tfae028","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:铝是一种公认的神经毒素,与多种神经退行性疾病有关。油杉(Moringa oleifera,M. oleifera)被称为神奇之树,可作为功能性食品和营养补充剂。本研究探讨了油橄榄提取物对氯化铝(AlCl3)诱导的大鼠大脑皮层神经退行性病变的潜在预防作用:将 24 只成年雄性 Wistar 大鼠随机分为四组:阴性对照组、油橄榄提取物(MOE)组、AlCl3 组和 AlCl3 + MOE 组。连续 28 天口服治疗。对认知能力、脑氧化/亚硝基应激、神经炎症、细胞凋亡以及相关的组织病理学改变进行了评估:结果表明:MOE改善了空间学习和记忆,提高了抗氧化剂超氧化物歧化酶的活性,拮抗了亚硝基应激,减少了炎症细胞因子(肿瘤坏死因子-α和白细胞介素-6),降低了caspase-3,增加了Bcl-2,并促进了大脑皮层和海马结构的修复:我们得出结论:MOE 对大脑皮层神经退行性变具有保护作用,使其成为一种很有前景的补充剂,可对抗铝引起的神经毒性效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Moringa oleifera leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats.

Background: Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. Moringa oleifera (M. oleifera), known as a miracle tree, is utilized as a functional food and nutritional supplement. This study investigates the potential preventive effects of M. oleifera extract on aluminum chloride (AlCl3)-induced cortical neurodegeneration in rats.

Materials and methods: Therefore, 24 adult male Wistar rats were randomly divided into four distinct groups: negative control, M. oleifera extract (MOE), AlCl3, and AlCl3 + MOE. Treatments were administered orally for 28 consecutive days. Cognitive performance, brain oxidative/nitrosative stress, neuroinflammation, apoptotic-cell death, and associated histopathological alterations were assessed.

Results: Our results showed that MOE improved spatial learning and memory, enhanced antioxidant superoxide dismutase enzyme activity, antagonized nitrosative stress, reduced inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), decreased caspase-3, increased Bcl-2, and facilitated repair of cortical and hippocampal structures.

Conclusions: We concluded that MOE exhibits protective effects against cortical neurodegeneration, making it a promising supplement to counteract aluminum-induced neurotoxic effects.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Toxicology Research
Toxicology Research TOXICOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
82
期刊介绍: A multi-disciplinary journal covering the best research in both fundamental and applied aspects of toxicology
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信