血管生成素/Tie2 系统在败血症中的作用:潜在的治疗靶点

IF 2.3 4区 医学 Q2 HEMATOLOGY
Yawen Chi, Sihan Yu, Jia Yin, Danyan Liu, Mengke Zhuo, Xu Li
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引用次数: 0

摘要

败血症是由严重感染引起的宿主反应紊乱,可导致危及生命的器官功能障碍。目前还没有治疗败血症的特效药。虽然有许多不同的病原体可导致败血症,但内皮功能障碍是导致血管渗漏和凝血问题的常见机制。最近关于血管内皮调节途径的研究表明,血管生成素(Ang)/Tie2 轴的紊乱可诱导内皮细胞活化,而这正是脓毒症的核心发病机制。在这篇综述中,我们旨在讨论脓毒症中血管生成素/Tie2 轴的调控和相关的生物标志物。此外,我们还试图探讨 Ang/Tie2 轴作为脓毒症干预潜在靶点以改善临床预后的前瞻性和可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Angiopoietin/Tie2 System in Sepsis: A Potential Therapeutic Target.

Sepsis is a disorder of host response caused by severe infection that can lead to life-threatening organ dysfunction. There is no specific treatment for sepsis. Although there are many different pathogens that can cause sepsis, endothelial dysfunction is a frequent mechanism resulting in vascular leakage and coagulation problem. Recent studies on the regulatory pathways of vascular endothelium have shown that the disturbance of angiopoietin (Ang) /Tie2 axis can induce endothelial cell activation, which is the core pathogenesis of sepsis. In this review, we aim to discuss the regulation of Ang/Tie2 axis and the biomarkers involved in the context of sepsis. Also, we attempt to explore the prospective and feasibility of Ang/Tie2 axis as a potential target for sepsis intervention to improve clinical outcomes.

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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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