病毒载体设计和优化治疗应用方面的技术进步。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Satyendra Singh, Anurag Kumar Pandey, Takhellambam Malemnganba, Vijay Kumar Prajapati
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引用次数: 0

摘要

病毒载体工程对生物技术、基因治疗和疫苗开发等多个领域的发展至关重要。这些载体由病毒产生,用于传递治疗基因或改变生物过程。病毒载体在提高治疗干预的精确性、安全性和效率方面的潜力促进了对它们的需求。本章讨论了技术进步和计算工具在建立病毒载体工程和载体优化以达到治疗目的方面的动态相互作用。本章还强调了硅学技术在最大限度地发挥载体治疗潜力方面的重要性,以及病毒载体工程的许多阶段,从基因组分析到计算机建模,以及提高基因精准传递的进步。高通量筛选推动了载体选择过程的加快,分析复杂的组学数据以进一步提高载体能力的计算技术也得到了讨论。硅学模型揭示了脱靶效应和整合位点,而载体的安全性(生物分布和毒性)仍然是关键部分,是临床前研究与临床研究之间的桥梁。尽管存在种种局限,但本章描绘了一个技术与计算融合的未来,它将把病毒载体疗法推向一个充满无限可能的时代。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Technological advancements in viral vector designing and optimization for therapeutic applications.

Viral vector engineering is critical to the advancement of several sectors of biotechnology, gene therapy, and vaccine development. These vectors were produced from viruses, were employed to deliver therapeutic genes or to alter biological processes. The potential for viral vectors to improve the precision, safety, and efficiency of therapeutic interventions has boosted their demand. The dynamic interplay between technological advancements and computational tools in establishing the landscape of viral vector engineering and vector optimization for therapeutic reasons is discussed in this chapter. It also emphasizes the importance of in silico techniques in maximizing vector potential for therapeutics and many phases of viral vector engineering, from genomic analysis to computer modelling and advancements to improve precise gene delivery. High-throughput screening propels the expedited process of vector selection, and computational techniques to analyze complex omics data to further enhance vector capabilities have been discussed. As in silico models reveal insights into off-target effects and integration sites, vector safety (biodistribution and toxicity) remains a crucial part and bridges the gap between preclinical and clinical investigations. Despite the limitations, this chapter depicts a future in which technology and computing merge to catapult viral vector therapy into an era of boundless possibilities.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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