蛋白质-蛋白质相互作用网络分析用于识别新型多靶点抑制剂和针对阿尔茨海默病的目标 miRNA。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Vinay Kumar, Kunal Roy
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引用次数: 0

摘要

本研究提出了一种提取重要基因复合物的策略,然后提供了治疗艾滋病的前瞻性疗法。在这项研究中,共检索到 1981 年至 2022 年间发表的 7905 篇报告。在对所有这些文章进行审查后,只考虑了有关 AD 的基因关联研究。最后,我们的数据集中列出了 453 个与阿尔茨海默病相关的基因,用于网络分析。为此,我们使用 Cytoscape v3.9.1 软件从 String 数据库中提取了实验得出的蛋白质-蛋白质相互作用(PPI)网络,并从中提取了四个在功能上相互关联的有意义的基因复合物。利用 ClueGO v2.5.9 工具对获得的基因复合物进行了富集分析,以强调最重要的生物过程和途径。随后,利用提取的基因复合物从 DGI v3.0 数据库中提取了与 AD 相关的药物,并介绍了一些可能对该疾病有帮助的新药。最后,一个包括与每个基因复合物组相连的每个基因以及每个基因的药物靶点的综合网络被展示出来。此外,我们还对所选化合物进行了分子对接研究,以确定其与相应靶点的相互作用模式。最后,我们提出了 62 个化合物作为多靶点定向类药物,其度值在 2 到 5 之间,30 个化合物作为靶点特异性类药物,这些化合物在之前的科学和医学研究中未被宣布为 AD 相关药物。随后,研究人员提出了可在未来工作中进行实验研究的新药物。此外,还利用 miRWalk v3 服务器建立了代表各组基因和目标 miRNA 的四个双方格网络,以引入目标 miRNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protein-protein interaction network analysis for the identification of novel multi-target inhibitors and target miRNAs against Alzheimer's disease.

This study presents a strategy for extracting significant gene complexes and then provides prospective therapeutics for AD. In this research, a total of 7905 reports published from 1981 to 2022 were retrieved. Following a review of all those articles, only the genetic association studies on AD were considered. Finally, there is a list of 453 Alzheimer-related genes in our dataset for network analysis. To this end, an experimentally derived protein-protein interaction (PPI) network from the String database was utilized to extract four meaningful gene complexes functionally interconnected using Cytoscape v3.9.1 software. The acquired gene complexes were subjected to an enrichment analysis using the ClueGO v2.5.9 tool to emphasize the most significant biological processes and pathways. Afterward, extracted gene complexes were used to extract the drugs related to AD from DGI v3.0 database and introduce some new drugs which may be helpful for this disease. Finally, a comprehensive network that included every gene connected to each gene complex group as well as the drug targets for each gene has been shown. Moreover, molecular docking studies have been performed with the selected compounds to identify the interaction pattern with the respective targets. Finally, we proposed a list of 62 compounds as multi-targeted directed drug-like compounds with a degree value between 2 and 5 and 30 compounds as target-specific drug-like compounds, which have not been proclaimed as AD-related drugs in prior scientific and medical investigations. Then, new drugs were suggested that can be experimentally examined for future work. In addition to this, four bipartite networks representing each group's genes and target miRNAs were established to introduce target miRNAs by using the miRWalk v3 server.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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