METTL3 作为癌症翻译的主调节器:机制与影响。

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
NAR cancer Pub Date : 2024-03-05 eCollection Date: 2024-03-01 DOI:10.1093/narcan/zcae009
Margalida Esteva-Socias, Francesca Aguilo
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引用次数: 0

摘要

翻译调控是控制基因表达的一个重要步骤。在癌细胞中,蛋白质合成的整体控制和特定 mRNA 的选择性翻译都会促进肿瘤细胞的存活、血管生成、转化、侵袭和转移。N6-甲基腺苷(m6A)是高等真核生物中最常见的 mRNA 修饰,会影响蛋白质的翻译。在过去十年中,m6A 绘图工具的开发促进了全面的功能研究,揭示了这种化学标记及其作者 METTL3 参与促进致癌基因和肿瘤抑制转录本的翻译,其影响取决于具体情况。本综述旨在巩固我们目前对 m6A 和 METTL3 如何在癌症生物学领域形成翻译调控的理解。此外,它还深入探讨了细胞质 METTL3 在蛋白质合成中的作用,这种作用与 METTL3 的催化活性无关。最终,我们的目标是提供有关癌症中 m6A、METTL3 和翻译调控之间相互作用的重要见解,从而更深入地理解维持肿瘤发生的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
METTL3 as a master regulator of translation in cancer: mechanisms and implications.

Translational regulation is an important step in the control of gene expression. In cancer cells, the orchestration of both global control of protein synthesis and selective translation of specific mRNAs promote tumor cell survival, angiogenesis, transformation, invasion and metastasis. N6-methyladenosine (m6A), the most prevalent mRNA modification in higher eukaryotes, impacts protein translation. Over the past decade, the development of m6A mapping tools has facilitated comprehensive functional investigations, revealing the involvement of this chemical mark, together with its writer METTL3, in promoting the translation of both oncogenes and tumor suppressor transcripts, with the impact being context-dependent. This review aims to consolidate our current understanding of how m6A and METTL3 shape translation regulation in the realm of cancer biology. In addition, it delves into the role of cytoplasmic METTL3 in protein synthesis, operating independently of its catalytic activity. Ultimately, our goal is to provide critical insights into the interplay between m6A, METTL3 and translational regulation in cancer, offering a deeper comprehension of the mechanisms sustaining tumorigenesis.

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CiteScore
6.90
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审稿时长
13 weeks
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