长寿命浆细胞在病毒清除中的作用。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-12-01 Epub Date: 2024-03-06 DOI:10.1080/17513758.2024.2325523

Mingran Zhang, Meili Li, Junling Ma

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引用次数: 0

摘要

适应性免疫系统有两种类型的浆细胞（PC），即长寿命浆细胞（LLPC）和短寿命浆细胞（SLPC），它们的寿命各不相同。在本文中，我们提出长寿命浆细胞除了在二次感染中减少病毒的基本繁殖数量外，对清除病毒颗粒也至关重要。我们利用一系列宿主内数学模型证明，CD8 T 细胞、SLPC 和记忆 B 细胞无法实现完全清除病毒，由于靶细胞的不断补充，病毒载量将达到较低的正平衡水平。然而，LLPC 的存在对病毒清除至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of long-lived plasma cells in viral clearance.

The adaptive immune system has two types of plasma cells (PC), long-lived plasma cells (LLPC) and short-lived plasma cells (SLPC), that differ in their lifespan. In this paper, we propose that LLPC is crucial to the clearance of viral particles in addition to reducing the viral basic reproduction number in secondary infections. We use a sequence of within-host mathematical models to show that, CD8 T cells, SLPC and memory B cells cannot achieve full viral clearance, and the viral load will reach a low positive equilibrium level because of a continuous replenishment of target cells. However, the presence of LLPC is crucial for viral clearance.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.