揭示神经回路:癫痫研究的技术、机遇和挑战。

IF 3.6 4区 医学 Q3 CELL BIOLOGY
Wenjie Xiao, Peile Li, Fujiao Kong, Jingyi Kong, Aihua Pan, Lili Long, Xiaoxin Yan, Bo Xiao, Jiaoe Gong, Lily Wan
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引用次数: 0

摘要

癫痫是一种常见的神经系统疾病,具有发病率高、复发率高和潜在耐药性等特点,严重影响着全球数百万人的生活。了解癫痫发作的微观机制对于有效治疗癫痫至关重要,而透彻了解癫痫背后错综复杂的神经回路对于开发靶向疗法和提高临床疗效也至关重要。本综述首先探讨了用于研究癫痫相关神经回路的技术的历史演变。然后,它广泛概述了这一领域所采用的各种技术,讨论了它们的基本原理、优势、局限性及其应用。此外,还总结了多种技术的综合应用,以揭示神经回路的复杂性。最后,本综述还介绍了与癫痫神经回路相关的靶向药物疗法。通过对癫痫神经回路研究中使用的方法进行批判性评估,本综述旨在加强对这些技术的理解,激发创新方法来揭示癫痫的复杂性,并最终促进癫痫治疗的改进和临床转化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research.

Epilepsy, a prevalent neurological disorder characterized by high morbidity, frequent recurrence, and potential drug resistance, profoundly affects millions of people globally. Understanding the microscopic mechanisms underlying seizures is crucial for effective epilepsy treatment, and a thorough understanding of the intricate neural circuits underlying epilepsy is vital for the development of targeted therapies and the enhancement of clinical outcomes. This review begins with an exploration of the historical evolution of techniques used in studying neural circuits related to epilepsy. It then provides an extensive overview of diverse techniques employed in this domain, discussing their fundamental principles, strengths, limitations, as well as their application. Additionally, the synthesis of multiple techniques to unveil the complexity of neural circuits is summarized. Finally, this review also presents targeted drug therapies associated with epileptic neural circuits. By providing a critical assessment of methodologies used in the study of epileptic neural circuits, this review seeks to enhance the understanding of these techniques, stimulate innovative approaches for unraveling epilepsy's complexities, and ultimately facilitate improved treatment and clinical translation for epilepsy.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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