[痕量胺相关受体 1 信号通路的研究进展]。

Q3 Medicine
生理学报 Pub Date : 2024-02-25
Meng Sun, Chen-Chen Zhang, Ji-Tao Li, Tian-Mei Si, Yun-Ai Su
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引用次数: 0

摘要

痕量胺相关受体1(TAAR1)是一种经典的G蛋白偶联受体,广泛分布于哺乳动物大脑,尤其是边缘系统和单胺类神经元丰富的区域,是所有物种中高度保守的TAAR亚型。TAAR1 能对中枢神经系统和外周组织中的内源性微量胺做出特异性反应,在单胺系统和谷氨酸系统失调导致精神障碍的病理生理机制中发挥着重要作用。此外,TAAR1 调节剂还能作用于内向整流钾通道,调节突触传递和神经元活动。最新研究发现,TAAR1 通过调控信号通路和底物磷酸化发挥一系列功能,与情绪、认知、恐惧和成瘾有关。因此,我们对 TAAR1 信号通路的相关研究进行了详细综述,旨在揭示 TAAR1 作为神经精神疾病药物治疗新靶点的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Research progress of trace amine-associated receptor 1 signaling pathways].

Trace amine-associated receptor 1 (TAAR1) is a classical type of G-protein-coupled receptor, which is widely distributed in the brain of mammals, especially in the limbic system and the region rich in monoaminergic neurons, and it is a highly conserved TAAR subtype in all species. TAAR1 can specifically respond to endogenous trace amines in the central nervous system and peripheral tissues, and plays an important role in the pathophysiological mechanisms involving the dysregulation of monoamine system and glutamate system leading to mental disorders. In addition, TAAR1 modulator can act on inwardly rectifying potassium channels and regulate synaptic transmission and neuronal activity. According to the latest research findings, TAAR1 exerts a series of functions by regulating signal pathways and substrate phosphorylation, which is related to emotion, cognition, fear and addiction. Therefore, we conducted a detailed review of relevant studies on the TAAR1 signaling pathways, aiming at revealing the great potential of TAAR1 as a new target for drug treatment of neuropsychiatric disorders.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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