药物基因组学在精准心理保健中的作用。

IF 1.2 4区 医学
Joshua M Hamilton
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引用次数: 0

摘要

摘要:药物基因组学是研究基因如何影响个人对药物的反应。这门科学催生了 "精准医疗 "的实践,它将药理学(对药物的研究)和基因组学(对基因及其功能的研究)结合起来,为更加个性化的治疗方法提供依据。相关的考虑因素包括针对不同的个体开具何种药物,以及何种剂量的药物治疗效果最好(副作用最小)。一个顽固性抑郁症和焦虑症病例(在慢性炎症和自身免疫性疾病的背景下)为精神药物基因组学的讨论提供了基础,为精神症状的更有效治疗方法提供了依据。现代人对神经生物学和神经病理学的理解,在基因和基因组信息的帮助下,为诊断和精准治疗常见的反复发作的精神健康问题提供了新的模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of pharmacogenomics in precision mental health care.

Abstract: Pharmacogenomics is the study of how genes affect a person's response to medications. This science has given rise to the practice of "precision health care," which combines pharmacology (the study of medication) and genomics (the study of genes and their functions) to inform a more personalized approach. Related considerations include which medications to prescribe to different individuals and what doses will have the most therapeutic effects (with the fewest side effects). A case of recalcitrant depression and anxiety (in the context of chronic inflammatory and autoimmune disease) serves as the basis for discussion of psychopharmacogenomics to inform a more effective treatment approach for psychiatric symptoms. A contemporary understanding of neurobiology and neuropathology, enhanced by genetic and genomic information, supports new models for diagnosis and precision treatment of commonly recurring mental health problems.

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来源期刊
自引率
16.70%
发文量
172
期刊介绍: The Journal of the American Association of Nurse Practitioners (JAANP) is a monthly peer-reviewed professional journal that serves as the official publication of the American Association of Nurse Practitioners. Published since 1989, the JAANP provides a strong clinical focus with articles related to primary, secondary, and tertiary care, nurse practitioner education, health policy, ethics and ethical issues, and health care delivery. The journal publishes original research, integrative/comprehensive reviews, case studies, a variety of topics in clinical practice, and theory-based articles related to patient and professional education. Although the majority of nurse practitioners function in primary care, there is an increasing focus on the provision of care across all types of systems from acute to long-term care settings.
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