老年扩张型心肌病患者血清钙水平的预后价值

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Global Heart Pub Date : 2024-02-28 eCollection Date: 2024-01-01 DOI:10.5334/gh.1304

Xinyi Li, Wenfei He, Qiqi Song, Qingshan Ding, Xiaonan Zhang, Zhigang Zeng, Weiping Deng, Gang Deng, Lichang Guan, Wanzi Hong, Yaoxin Liu, Fen Shu, Lishu Xu, Ning Tan, Jinjin Ma, Lei Jiang

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引用次数: 0

摘要

背景：入院时的血清钙与扩张型心肌病（DCM）的临床预后是否相关尚不清楚。在本研究中，我们进行了一项跨越十年的回顾性研究，以探讨基线血钙在老年 DCM 患者中的预后价值：方法：2010 年 1 月至 2019 年 12 月期间，我们回顾性纳入了 1089 名连续确诊为 DCM 的老年患者（年龄≥60 岁）。进行单变量和多变量分析，研究血清钙与临床预后的关系：研究对象的平均年龄为（68.36±6.31）岁。接收者操作特征曲线（ROC）分析表明，血清钙水平对预测院内死亡具有很高的灵敏度和特异性，AUC 为 0.732。卡普兰-梅耶生存分析显示，血清钙>8.62 mg/dL的患者比血清钙≤8.62 mg/dL的患者预后更好（log-rank χ2 40.84，P <0.001）。在对几种常见风险因素进行调整后，血清钙≤8.62 mg/dL与较高的长期死亡风险有关（HR：1.449；95% CI：1.115~1.882；P = 0.005）：结论：血清钙水平可作为评估 DCM 患者预后的一种简单、经济的工具。

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The Prognostic Value of Serum Calcium Levels in Elderly Dilated Cardiomyopathy Patients.

Background: It is unclear whether serum calcium on admission is associated with clinical outcomes in dilated cardiomyopathy (DCM). In this study, we conducted a retrospective study spanning a decade to investigate the prognostic value of baseline calcium in elderly patients with DCM.

Methods: A total of 1,089 consecutive elderly patients (age ≥60 years) diagnosed with DCM were retrospectively enrolled from January 2010 to December 2019. Univariate and multivariate analyses were performed to investigate the association of serum calcium with their clinical outcomes.

Results: In this study, the average age of the subjects was 68.36 ± 6.31 years. Receiver operating characteristic (ROC) curve analysis showed that serum calcium level had a great sensitivity and specificity for predicting in-hospital death, with an AUC of 0.732. Kaplan-Meier survival analysis showed that patients with a serum calcium >8.62 mg/dL had a better prognosis than those with a serum calcium ≤8.62 mg/dL (log-rank χ² 40.84, p < 0.001). After adjusting for several common risk factors, a serum calcium ≤8.62 mg/dL was related to a higher risk of long-term mortality (HR: 1.449; 95% CI: 1.115~1.882; p = 0.005).

Conclusions: Serum calcium level could be served as a simple and affordable tool to evaluate patients' prognosis in DCM.

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来源期刊

Global Heart Medicine-Cardiology and Cardiovascular Medicine

CiteScore

5.70

自引率

5.40%

发文量

审稿时长

5 weeks

期刊介绍： Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.