Michele Sassano, Monireh Sadat Seyyedsalehi, Giulia Collatuzzo, Claudio Pelucchi, Rossella Bonzi, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Zuo-Feng Zhang, Lizbeth López-Carrillo, Nuno Lunet, Samantha Morais, David Zaridze, Dmitry Maximovich, Vicente Martín, Gemma Castano-Vinyals, Jesús Vioque, Sandra González-Palacios, Mary H Ward, Reza Malekzadeh, Mohammadreza Pakseresht, Raul Ulises Hernández-Ramirez, Malaquias López-Cervantes, Eva Negri, Federica Turati, Charles S Rabkin, Shoichiro Tsugane, Akihisa Hidaka, Areti Lagiou, Pagona Lagiou, M Constanza Camargo, Maria Paula Curado, Stefania Boccia, Carlo La Vecchia, Paolo Boffetta
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Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC.</p><p><strong>Methods: </strong>Fourteen case-control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose-response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials.</p><p><strong>Results: </strong>Individuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). 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引用次数: 0
摘要
背景：以往的研究表明，膳食中的维生素 C 与胃癌（GC）呈反向关系，但大多数研究并未考虑水果和蔬菜的摄入量。因此，我们旨在胃癌汇集（StoP）项目（胃癌流行病学研究联盟）中评估这种相关性：分析包括 14 项病例对照研究（5362 例病例，11497 例对照）。我们估算了膳食中维生素 C 摄入量与 GC 之间关系的几率比（ORs）和相应的 95% 置信区间（CIs），并对相关混杂因素以及水果和蔬菜的摄入量进行了调整。剂量-反应关系采用二阶分数多项式混合效应逻辑模型进行评估：结果：膳食维生素 C 摄入量最高四分位数的人与最低四分位数的人相比，患 GC 的几率有所降低（OR：0.64；95% CI：0.58，0.72）。对水果和蔬菜摄入量进行额外调整后，OR 值为 0.85（95% CI：0.73，0.98）。在非心绞痛性 GC 以及肠道型和弥漫型 GC 中均观察到了明显的负相关。剂量反应分析的结果显示，维生素 C 摄入量达到 150-200 毫克/天时，GC 的 ORs 下降（OR：0.54；95% CI：0.41，0.71），而维生素 C 摄入量越高，ORs 越接近 1.0：我们的汇总研究结果表明，维生素 C 与 GC 呈反向关系，摄入量超过目前推荐的每日摄入量（男性 90 毫克，女性 75 毫克）也可能产生有益影响。
Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project.
Background: Previous studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC.
Methods: Fourteen case-control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose-response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials.
Results: Individuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose-response analysis showed decreasing ORs of GC up to 150-200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0.
Conclusions: The findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).
期刊介绍：
Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide.
The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics.
Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field.
With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.
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