通过可见光诱导 N-Cyanamide 烯的多米诺二氟烷基化/环化反应获得含 CF2COR 的喹唑啉酮。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-03-04 DOI:10.1021/acs.orglett.4c00457

Yangyang Cui, Wen Xu, Wenchao Yang* and Fei Meng*,

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引用次数: 0

摘要

我们开发了一种绿色高效的可见光诱导自由基级联二氟烷基化/环化 N-氰酰胺烯反应。利用廉价的非金属 4CzIPN 作为光催化剂，高产率地获得了多种含 CF2COR 的喹唑啉酮。这种光催化反应为获得有价值的多环喹唑啉酮提供了快速、简便和实用的途径，而且可以达到克级规模。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Access to CF2COR-Containing Quinazolinones via Visible-Light-Induced Domino Difluoroalkylation/Cyclization of N-Cyanamide Alkenes

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Access to CF2COR-Containing Quinazolinones via Visible-Light-Induced Domino Difluoroalkylation/Cyclization of N-Cyanamide Alkenes

A green and highly efficient visible-light-induced radical cascade difluoroalkylation/cyclization reaction of N-cyanamide alkenes has been developed. A variety of CF₂COR-containing quinazolinones have been obtained in high yields with cheap non-metallic 4CzIPN as the photocatalyst. This photocatalytic reaction provides rapid, facile, and practical access to valuable polycyclic quinazolinone, and it is amenable to the gram scale.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.