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VMAT 结构揭示了令人兴奋的药物开发目标。

IF 13.9 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Trends in pharmacological sciences Pub Date : 2024-05-01 Epub Date: 2024-02-29 DOI:10.1016/j.tips.2024.02.004
Shimon Schuldiner, Lucy R Forrest
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引用次数: 0

摘要

囊泡单胺转运体（VMAT）-2 在生物胺的神经传递中起着至关重要的作用。最近，Dalton 等人、Pidathala 等人、Wu 等人和 Wang 等人分别报告了人 VMAT2 的冷冻电镜（EM）结构，为开发改良治疗药物和深入了解该蛋白的功能提供了机会。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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VMAT structures reveal exciting targets for drug development.

Vesicular monoamine transporter (VMAT)-2 has a crucial role in the neurotransmission of biogenic amines. Recently, Dalton et al., Pidathala et al., Wu et al., and Wang et al. individually reported cryo-electron microscopy (EM) structures of human VMAT2, offering opportunities for developing improved therapeutics and deep insights into the functioning of this protein.

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来源期刊
Trends in pharmacological sciences
Trends in pharmacological sciences 医学-药学
CiteScore
23.90
自引率
0.70%
发文量
132
审稿时长
6-12 weeks
期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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