血清肉碱水平低与妊娠晚期尿肉碱排泄量增加有关。

IF 2.1 4区医学 Q3 MEDICAL LABORATORY TECHNOLOGY

Annals of Clinical Biochemistry Pub Date : 2024-09-01 Epub Date: 2024-03-20 DOI:10.1177/00045632241239806

Yutaro Kobori, Satoshi Hirayama, Yoshifumi Fukushima, Tsuyoshi Ueno, Kazumasa Sekihara, Atsushi Hori, Yuna Horiuchi, Shintaro Makino, Emiko Nishioka, Takashi Miida

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引用次数: 0

摘要

背景：肉碱是脂肪酸代谢所必需的物质。游离肉碱（FCA）通过肾小球随尿液排出，但部分被肉碱转运体重吸收。妊娠期血清肉碱水平下降的机制尚不清楚：目的：研究低肉碱水平是否与孕妇肾脏排泄增加有关：我们招募了 43 名健康孕妇和 25 名非孕妇。方法：我们招募了 43 名健康孕妇和 25 名非孕妇，采用酶循环法测量总肉碱（TCA）和 FCA 水平，并计算酰基肉碱（ACA）水平。按肉碱清除率除以肌酐清除率计算分数排泄量（FE）：妊娠 12 周时，孕妇的三氯乙酸、三氯乙酸酰肌氨酸和三氯乙酸酰肌氨酸平均水平低于非孕妇（P < 0.001）；妊娠 36 周时，孕妇的三氯乙酸、三氯乙酸酰肌氨酸和三氯乙酸酰肌氨酸平均水平进一步下降，分别为非孕妇的 39%、36% 和 52%（P < 0.001）。孕妇的 FEs 是非孕妇的 3-4 倍。孕妇的血清 FCA/TCA 比值低于非孕妇（分别为 0.830 ± 0.074 vs. 0.788 ± 0.098；p < 0.05），而尿液 FCA/TCA 比值在两组之间相似：结论：肉碱水平低与妊娠晚期肾脏排泄增加有关。

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Low serum carnitine level is associated with increased urinary carnitine excretion in late pregnancy.

Background: Carnitine is essential for fatty acid metabolism. Free carnitine (FCA) is excreted in the urine in the glomerulus, but is partly reabsorbed by a carnitine transporter. The mechanism underlying the decrease in serum carnitine level during pregnancy is unclear.

Objective: To investigate whether low carnitine level is associated with increased renal excretion in pregnant women.

Methods: We recruited 43 healthy pregnant and 25 non-pregnant women. Total carnitine (TCA) and FCA levels were measured using the enzymatic cycling method, and the acylcarnitine (ACA) level was calculated. Fractional excretion (FE) was calculated as carnitine clearance divided by creatinine clearance.

Results: The mean TCA, FCA, and ACA levels were lower at 12 weeks of gestation in pregnant than non-pregnant women (P < .001); the levels decreased further at 36 weeks, reaching 39%, 36%, and 52% of those in non-pregnant women, respectively (P < .001). The FEs were 3-4-fold higher in pregnant women than non-pregnant women. Pregnant women had a lower serum FCA/TCA ratio than non-pregnant women (0.788 ± 0.098 vs 0.830 ± 0.074, respectively; P < .05), whereas the urine FCA/TCA ratio was similar between the groups.

Conclusion: Low carnitine level is associated with increased renal excretion during late pregnancy.

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来源期刊

Annals of Clinical Biochemistry Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

5.20

自引率

4.50%

发文量

期刊介绍： Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine. Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal''s scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals. Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).